赖诺普利与贝那普利治疗高血压合并脑卒中的疗效及对血清ADMA水平的影响

Effect of Lisinopril and Benner Pury in the Treatment of Hypertensive Stroke and Effect on Serum ADMA Level

目的:探讨赖诺普利与贝那普利治疗高血压合并脑卒中的疗效及对血清非对称性二甲基精氨酸(ADMA)水平的影响,以期为高血压合并脑卒中的治疗提供指导。方法:选取2014年1月-2016年3月在我院确诊并接受治疗的高血压合并脑卒中246例,按随机数字表法将患者随机分为研究组、对照组和常规组,每组各82例。常规组采用基础治疗,研究组采用基础治疗联合赖诺普利治疗,对照组采用基础治疗联合贝那普利治疗。比较3组患者治疗前后血压参数、血清ADMA和Hcy水平、治疗效果和不良反应。结果:治疗前三组患者的血压参数(SBP、DBP和PP)、血清ADMA和Hcy水平、m RS评分均无显著差异;治疗后三组患者上述指标水平较治疗前均显著降低(P<0.05),且研究组患者指标水平明显低于对照组和常规组(P<0.05)。研究组治疗有效率明显高于对照组和常规组,对照组治疗有效率明显高于常规组,上述差异均具有统计学意义(P<0.05)。三组患者不良反应率无显著差异(P>0.05)。结论:赖诺普利和贝那普利均能有效降低高血压合并脑卒中患者血压水平,改善血管内皮功能,疗效显著;但赖诺普利的效果要比贝那普利更好,更值得临床推广。

Objective：To evaluate the clinical efficacy of lisinopril and Benner Pury in the treatment of hypertensive stroke and on serum asymmetric dimethylarginine （ADMA two） levels,in order to provide guidance for the treatment ofhypertension and stroke.Methods：246 cases of hypertensive stroke from January 2014-March 2016 who received treatment in our hospital diagnosed,according to the random number table method were randomly divided into study group compare group and conventional group,82 cases in each group.The conventional group received basic treatment,study group with basic treatment combined with lisinopril treatment,the control group was treated with combined therapy of Benner Pury treatment.The blood pressure parameters,serum ADMA and Hcy levels,treatment effects and adverse reactions were compared between the 3 groups before and after treatment.Results：There were no significant differences in the blood pressure,serum ADMA and Hcy levels and mRS scores of the three groups of patients before treatment （SBP,DBP and PP）;the index levels after treatment were significantly lower than before treatment （P〈0.05）,and the index of patients in the study group was significantly lower than the control group and normal group （P〈0.05）.The effective rate of the treatment group was significantly higher than that of the control group and the conventional group,the effective rate of the treatment group was signifi-cantly higher than that of the conventional group,the difference was statistically significant （P〈0.05）.There was no significant difference in adverse reaction rate between the three groups （P〉0.05）.Conclusion：Lisinopril and Benner Pury can effectively lower blood pressure in hypertensive patients with cerebral stroke,improve endothelial function,with significant effect;but the effect of lisinopril to is better than Benner Pury,more worthy of promotion.