SIRT3与细胞凋亡的研究进展

Progress of Correlation between SIRT3 and Cells Apoptosis

SIRT3是哺乳动物体内"sirtuin家族"7成员之一,是一种NAD依赖的组蛋白去乙酰化酶,主要存在于线粒体内。SIRT3存在两种形式:44 kDa的长链和28 kDa的短链,其在细胞内主要通过短链SIRT3发挥作用。SIRT3通过其酶催化活性,除了可调节机体能量代谢、细胞衰老以及肿瘤形成等生命过程外,SIRT3对于细胞凋亡也起到举足轻重的调节作用。目前的研究表明,在细胞凋亡中,SIRT3可能存在双向调节作用,即通过不同的信号通路的作用,SIRT3可促进/抑制细胞凋亡而发挥一系列的生物学效应,而有关于SIRT3调节细胞凋亡更详尽的分子机制还有待深入研究。

SIRT3 is one of the seven members of＂Sirtuin family＂ inside the mammals.It is a kind ofhistone deacetylase mainly existed in the mitochondria as the dependence of NAD.SIRT3 has two kinds of forms：a long chain length of 44 kDa and a short chain length of 28 kDa,SIRT3 plays a role in the intracellular mainly through the short chain.In addition to regulates the body＇s energy metabolism,cell senescence and tumorigenesis of life process,SIRT3 also plays a regulatory role for apoptosis through its catalytic activity of enzyme.Current research suggests that SIRT3 probably has the function of bidirectional regulation in apoptosis,it means through different signal pathway,SIRT3 can promote/inhibit apoptosis so that induces a series of biological effects,but the molecular mechanism of regulation of apoptosis is more detailed and need further research.