丹蒌片治疗老年性主动脉瓣狭窄的临床疗效分析

Analysis of the Therapeutic Effect of Dan Lou Tablet on the Degenerative Aortic Calcification in Elderly Patients

目的:探讨丹蒌片对老年性主动脉瓣狭窄患者临床疗效及血清炎症因子水平的影响。方法:选取老年性主动脉瓣钙化患者共34例,将其随机分为丹蒌片治疗组(22例)及对照组(12例)。根据西雅图心绞痛问卷中文版、SF-36生活质量量表、中医临床证候评分比较两组的治疗效果,ELISA检测治疗前后患者血清肿瘤坏死因子α(TNF-α)、白介素6(IL-6)及同型半胱氨酸(HCY)的水平。结果:丹蒌片治疗组患者心绞痛程度及治疗满意度较常规治疗组均有明显统计学差异,丹蒌片可提高病人生活质量,改善中医部分证候,减轻血清炎症因子表达。结论:丹蒌片或可减缓主动脉瓣钙化进展,其原因可能和炎症反应减轻有关。

Objective： To investigate the effect of Dan Lou tablet on the efficacy and expression of serum inflammatory factors in elderly patients with degenerative aortic calcification. Methods： A total of 34 cases of aortic valve calcification patients were randomly divided into two groups, the treatment group and the control group, 22 patients in Dan Lou tablet group, 12 patients in the control group. The efficacy was compared between two groups according to the Seattle angina questionnaire in Chinese version, SF-36 scale of quality of life, TCM clinical syndrome score. The serum TNF-α, IL-6 and HCY levels were detected by ELISA before and after treatment. Results： The improvement of angina pectoris degree and the degree of satisfaction were superior in the treatment group than those of the control group, Dan Lou Tablet could enhance the quality of life, improve syndrome and reduce serum inflammatory factors levels of patients. Conclusions： Dan Lou tablet could slow down the progression of aortic valve calcification, which might be related to attenuate the inflammation.