髓芯减压联合干细胞移植治疗股骨头坏死患者的临床疗效及机制研究

A Study on the Effect and Mechanism of Core Decompression combined with Stem Cell Transplantation on Patients with Femoral Head Necrosis

目的:探讨采用髓芯减压与干细胞移植联合治疗股骨头坏死患者的临床疗效及可能机制。方法:选择我院确诊并治疗的股骨头患者76例作受试者,按随机数字表法分为两组,对照组38例采用干细胞移植治疗,治疗组38例在对照组基础上联合髓芯减压疗法。观察和比较两组患者的临床疗效、髋关节Harris评分及治疗前后血清PINP(Ⅰ型前胶原氨基端前肽)、CTX(Ⅰ型胶原C端肽)、OST(骨钙素)水平的变化情况。结果:治疗组总有效率及Harris评分均显著高于对照组(P<0.05);治疗组患者血清PINP、CTX、OST水平较治疗前明显下降,并显著低于对照组,差异具有统计学意义(P<0.05)。结论:髓芯减压与干细胞移植的联合应用可提高股骨头坏死患者的临床疗效和髋关节功能,可能与其降低患者血清PINP、CTX、OST水平有关。

Objective： To investigate the effects of core decompression combined with stem cell transplantation on the serum levels of PINP, CTX and OST in patients with femoral head necrosis and its clinical efficacy. Methods： 76 patients with femoral head necrosis who were diagnosed and treated in our hospital were selected and randomly divided into two groups, with 38 cases in each group. The patients in the control group were treated with stem cell transplantation, while the patients in the experimental group were treated with core decompression therapy on the basis of the control group. Then the hip Harris score and the serum levels of PINP, CTX and OST of patients in the two groups were observed and compared before and after treatment. Results： The total effective rate and Harris score of experimental group were higher than those of the control group （P〈0.05）. The serum levels of PINP, CTX and OST in the experimental group were obviously deerea^d, which were significantly lower than those of the control group （P〈0.05）. Conclusion： Core decompression combined with stem cell transplantation could improve the efficacy and function of hip joint, it might be related to the reduction of serum levels ofPINP, CTX and OST levels.