小柴胡颗粒联合盐酸氨溴索雾化对慢性支气管炎急性发作期患者临床疗效的影响

Clinical Effect of Xiaochaihu Particles plus Nebulization by Ambroxol Hydrochloride on the Acute Exacerbation of Chronic Bronchitis

目的:研究小柴胡颗粒联合盐酸氨溴索雾化治疗慢性支气管炎急性发作期的临床效果及对炎症因子的影响。方法:选择2016年1月至2016年7月我院治疗的160例慢性支气管急性发作患者作为研究对象,按照治疗方法将其分为观察组和对照组,对照组使用盐酸氨溴索雾化吸入方式治疗,观察组在此基础上联合服用小柴胡颗粒治疗,观察比较两组患者治疗后临床效率、临床症状消失时间以及治疗前后两组患者肺功能、炎症因子水平的变化。结果:观察组总有效率高于对照组,两组比较差异显著(P<0.05);观察组的血清IL-6、IL-8、TFN-α水平明显低于对照组,且肺功能、临床症状消失时间均明显的优于对照组,差异具有统计学意义(P<0.05)。结论:使用小柴胡颗粒联合盐酸氨溴索雾化治疗急性发作期的慢性支气管炎患者能显著的缩短其临床症状消失时间,改善患者的肺功能,提高其临床疗效,可能与其有效抑制炎症反应有关。

Objective：To study the clinical effect of Xiaochaihu particles plus nebulization by ambroxol hydrochloride on the acute exacerbation of chronic bronchitis and its influence on the inflammatory cytokines.Methods：160 paticnts with acute exacerbation of chronic bronchitis who received therapy from January 2016 to July 2016 in our hospital were selected as research objects and divided into the observation group and control group according to the method of treatment,the control group was given hydrochloric acid ammonia bromine atomization inhalation treatment,the observation group was treated on the basis of control group combined with the small bupleurum granule,the clinical efficiency and clinical symptoms disappearence time,pulmonary function and inflammatory factors levels of two groups of patients before and after treatment were compared.Results：After treatment,the total effective rate of observation group was as high as 96.3%,which was significantly higher than that of the control group （85.0%,P〈0.05）.After treatment,the serum IL-6,IL-8,TFN-α levels of observation group were obviously lower than those of the control group （P〈0.05）,the pulmonary function,clinical symptoms disappearence time were significantly better than those of the control group （P〈0.05）.Conclusion：Small radix bupleuri particles plus nebulization by ambroxol hydrochloride could significantly shorten the clinical symptoms disappearence time,improve the lung function and clinical curative effect of acute exacerbation of chronic bronchitis,which might be related to the inhibition of inflammatory response.