卡介菌多糖核酸对慢性阻塞性肺疾病患者炎症因子水平及免疫功能的影响

Effect of Bacillus Calmette-guerin Polysaccharide Nucleic Acid on the Inflammatory Factors and Immune Functions of Patients with Chronic Obstructive Pulmonary Disease

目的:分析卡介菌多糖核酸对慢性阻塞性肺疾病患者炎症因子水平及免疫功能的影响。方法:随机将110例慢性阻塞性肺疾病患者分为对照组与观察组,每组55例。对照组采用常规治疗,观察组在常规治疗基础上加用卡介菌多糖核酸治疗,比较两组临床疗效,血清单核细胞样受体4(TLR4)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、脂质过氧化物(LPO)、超氧化物歧化酶(SOD)、金属蛋白抑制1(TIMP-1)及金属蛋白酶-9(MMP-9)水平,CD4^+、CD4^+/CD8^+、CD8^+水平,第1秒用力呼气容积(FEV1)、肺活量(FVC)。结果:观察组总有效率为96.86%,显著高于对照组81.82%,差异有统计学意义(P<0.05)。治疗后,观察组血清TLR4、IL-8、TNF-α、LPO、TIMP-1、MMP-9、HMGB1水平、FEV1、FVC及CD8^+低于对照组,SOD水平、CD4+、CD4+/CD8^+高于对照组,差异均有统计学意义(P<0.05)。结论:卡介菌多糖核治疗慢性阻塞性肺疾病的临床疗效肯定,可选择性减轻炎症反应并改善免疫功能。

Objective：To analyze the effect of bacillus calmette-guerin polysaccharide nucleic acid on the inflammatory factor levels and immune function of patients with chronic obstructive pulmonary disease.Methods：110 eases of chronic obstructive pulmonary disease patients were divided into the control group and the observation group according to the random number table method,55 cases in the control group was given conventional treatment,while the observation group was given bacillus calmette-guerin polysaccharide nucleic acid on the basis of control group,the clinical curative effect,monocyte like receptor 4 （TLR4）,serum interleukin 8 （IL-8）,tumor necrosis factor-α（TNF-α）,lipid peroxide （LPO） and superoxide dismutase （SOD）,metal protein-1 （TIMP-1） and metalloproteinases-9 （MMP-9）,CD4＋,CD4＋/CD8＋,CD8＋,forced expiratory volume in 1 second （FEV1） and forced vital capacity （FVC） between two groups were compared.Results：The total effective rate of observation group was 96.86%,which was significantly higher than that of control group （81.82%,P〈0.05）.After treatment,the TLR4,IL-8,serum TNF-α,LPO,MMP-9 and TIMP-1,HMGB1 level,FEV1 and FVC and CD8^＋ of observation group were lower than those of the control group,the SOD level,CD4^＋,CD4^＋/CD8^＋ of observation group were higher than those of the control group （P〈0.05）.Conclusion：Polysaccharide core of bacillus calmette-guerin had good clinical efficacy in the treatment of chronic obstructive pulmonary disease,which could selectively reduce the inflammatory response and improve the immune function.