摘要
目的:探讨甲氨蝶呤(MTX)或来氟米特(LEF)联合泼尼松(PDN)对老年类风湿关节炎的疗效。方法:选取112例老年RA患者,按随机数表法将患者分为LEF组(n=28)、MTX组(n=28)、LET+PDN组(n=28)、MTX+PDN组(n=28),治疗3个月后统计四组关节肿胀数、关节压痛数、DAS28评分、VAS评分、RF、晨僵时间,并记录不良反应事件。结果:MTX组和LEF组治疗后各项指标均低于治疗前(P<0.05);MTX+PDN组与LEF+PDN组治疗后各项指标均明显低于治疗前(P<0.001);MTX+PDN组治疗效果明显优于MTX组(P<0.001);LEF+PDN组治疗效果明显优于LEF组(P<0.001);MTX+PDN组治疗总有效率为53.57%,高于LEF+PDN组的42.86%,但差异无统计学意义(x^2=2.426,P=0.119)。结论:四组对RA均有治疗效果,联合使用效果更佳,且服药后无严重不良反应,安全性较高。
Objective:To investigate the curative effect ofmethotrexate (MTX) or leflunomide (LEF) in combination with prednisone (PDN) in the treatment of senile rheumatoid arthritis (RA).Methods:112 elderly patients with RA in our hospital between May 2013 and November 2015 were selected.All patients were divided into LEF group (n=28),MTX group (n=28),LET+PDN group (n=28),MTX+PDN group (n=28) according to the random number table method.After 3 months of treatment,calculate the swollen joints,joint tendemess,DAS28 score,VAS score,RF,morning stiffness time and record the adverse events.Results:The indexes of MTX group and LEF group after treatment were significantly lower than before treatment (P〈0.05).The indexes of MTX+PDN group and LEF+PDN group were also significantly lower after treatment than before treatment,and the difference was statistically significant (P〈0.001).MTX+PDN group showed significantly better effect than MTX group (P〈0.001),and LEF+PDN group also showed significantly better effect than LEF group (P〈0.001).The total effective rate of MTX+PDN group was 53.57%,higher than that of 42.86% in LEF+PDN group,but the difference was not statistically significant (x^2=2.426,P=0.119).Conclusion:The four groups all had curative effect,but the combination of two had better effect,and there were no serious adverse reactions after treatment.The efficacy difference between MTX+PDN group and LEF+PDN group was not distinct,so they can be selected according to the actual situation.
出处
《现代生物医学进展》
CAS
2017年第15期2903-2906,共4页
Progress in Modern Biomedicine
基金
新疆维吾尔自治区自然科学基金项目(2014211C078)