阻塞性黄疸患者总胆汁酸的表达及与血脂水平的关系研究

Study of Total Bile Acid and Blood Lipid Levels in Patients with Obstructive Jaundice

目的:探讨阻塞性黄疸(OJ)患者血清总胆汁酸(TBA)水平与血脂水平的关系。方法:选择2015年5月到2015年12月我院收治的70例OJ患者作为观察组,同期选择70例健康人员作为对照组。检测并比较两组血清TBA、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白AI(Apo AI)、载脂蛋白B(Apo B)、脂蛋白α[Lp(α)]、总胆红素(T-Bil)及直接胆红素(D-Bil)水平,并分析血清TBA与血脂水平的关系。结果:观察组患者的血清TBA、TG、TC、Apo B、T-Bil及D-Bil水平均明显低于对照组,血清LDL-C、HDL-C、Apo AI及Lp(α)水平均明显高于对照组,差异均具有统计学意义(P<0.05)。Pearson直线相关性分析结果表明,血清TBA水平与血清TG、TC、Apo B、T-Bil及D-Bil呈正相关性,与血清LDL-C、HDL-C、Apo AI及Lp(α)水平呈负相关性。结论:OJ患者体内存在血脂水平紊乱,血清TBA可能是导致OJ患者血脂代谢紊乱的重要因素。

Objective：To investigate the correlation between total bile acid （TBA） and blood lipid levels in patients with obstructive jaundice （OJ）.Methods：A total of 70 OJ patients in our hospital were included as the observation group from may 2015 to December 2015,contemporaneous 70 healthy persons were selected as the control group.The serum TBA,triacylglycerol （TG）,total cholesterol （TC）,low density lipoprotein cholesterin （LDL-C）,high density lipoprotein cholesterin （HDL-C）,Apolipoprotein AI （Apo AI）,Apolipoprotein B （Apo B）,lipoprotein（a）[Lp（α）],total bilirubin （T-Bil） and direct bilirubin （D-Bil） of the two groups were compared.Analyzed the correlation between TBA and blood lipid levels.Results：The serum TBA,TG,TC,Apo B,T-Bil and D-Bil of the observation group were were significantly lower than the control group （P〈0.05）,while the serum LDL-C,HDL-C,Apo AI and Lp（α） of the observation group were were significantly higher than the control group（P〈0.05）.Pearson correlation analysis results showed that TBA was positively correlated with TG,TC,Apo B,T-Bil,D-Bil,and negatively correlated with LDL-C,HDL-C,Apo AI,Lp （α）.Conclusion：The lipid metabolism is disorder in patients with O J,TBA may play an important role in promoting the disorder of lipid metabolism.