参苓白术辅助治疗对老年溃疡性结肠炎伴脓血便患者临床疗效及免疫功能的影响

Influence of Adjunctive Therapy with Shenling Baizhu Powder on the Immune Function and Clinical Effect of Elderly Patients with Colitis Gravis and Bloody Purulent Stool

目的:探讨参苓白术辅助治疗对老年溃疡性结肠炎伴脓血便患者临床疗效及免疫功能的影响。方法:选取于我院进行治疗的老年溃疡性结肠炎伴脓血便患者50例,随机分为实验组与对照组,每组25例。对照组患者给予柳氮磺吡啶结肠溶胶囊进行治疗,实验组患者在对照组的基础上联合使用参苓白术丸进行治疗,两组患者均治疗3个月,比较两组患者治疗前后血清白介素-2(IL-2)、γ-干扰素(IFN-γ)及白介素-10(IL-10)水平,并评价两组患者的临床疗效。结果:与治疗前相比,两组患者治疗后的血清IL-2、IFN-γ水平均显著降低,IL-10明显升高;与对照组相比,实验组患者血清IL-2、IFN-γ水平较低,IL-10水平更高(P<0.05);且与对照组相比,实验组患者的临床总有效率较高(P<0.05)。结论:参苓白术散能有效改善老年溃疡性结肠炎伴脓血便患者的免疫功能并提高其临床疗效。

Objective：To investigate the influence of shenling baizhu powder on the immune function and clinical effect of elderly patients with colitis gravis and bloody purulent stool.Methods：50 elderly patients with colitis gravis and bloody purulent stool who were treated in our hospital were selected and randomly divided into the experimental group and control group with 25 cases in each group,patients in the control group were treated with sulfasalazine colonosoluble capsules,patients in the experimental group were treated on the base of the control group with shenling baizhu powder,patients in both groups of were treated for 3 months,the serum intedeukin 2 （IL-2）,γ-interferon （IFN-γ） and interleukin 10 （IL-10） levels of both groups were compared before and after treatment,and the clinical efficacy of the two groups of patients were evaluated.Results：Compared with before treatment,the serum IL-2,IFN-γ IL-10 levels of both groups were obviously decreased after treatment;compared with the control group,the serum IL-2,IFN-γ and IL-10 levels of experimental group were significantly lower （P〈0.05）;and compared with the control group,the total clinical effective rote of experimental group was higher （P〈0.05）.Conclusion：Shenling baizhu powder could effectively improve the immune function and clinical effect of elderly patients with colitis gravis and bloody purulent stool.