血浆D-二聚体、纤维蛋白原水平与骨创伤患者创伤程度的相关性

Correlation of the Plasma D-dimer, Fibrinogen Levels with the Traumatic Degree of Patients with Orthopedic Trauma

目的:分析骨创伤患者的血浆D-二聚体、纤维蛋白原水平及其与创伤程度的相关性。方法:收集2015年1月至2016年1月我院收治的骨创伤患者180例作为观察组,选择同期接受体检的健康者100例作为对照组。动态监测两组受检者入院后第1、3、6、10 d的血浆D-二聚(DD)和纤维蛋白原(FIB)的水平,并分析DD和FIB水平与骨创伤程度的相关性。结果:入院后第1、3、6、10 d,观察组的FIB和DD水平均出现下降趋势,但均显著高于对照组,差异具有统计学意义(P<0.05)。重度创伤组和中度创伤组患者的FIB水平显著高于轻度创伤组,且重度创伤组FIB水平显著高于中度创伤组,组间比较差异均具有统计学差异(P<0.05)。从入院第1 d至10 d,3组患者的FIB水平均出现显著降低(P<0.05)。轻度创伤组患者的DD水平最低,其次是中度创伤组,重度创伤组最高,组间比较差异均具有统计学差异(P<0.05)。从入院第1 d至10 d,3组患者的DD水平均出现显著降低(P<0.05)。此骨创伤患者创伤严重程度与FIB和DD的水平均呈现出显著正相关关系(r=0.64,P=0.003;r=0.71,P=0.002)。结论:骨创伤患者的血浆FIB和DD水平显著高于健康人,与创伤程度呈显著正相关,可能作为骨创伤患者病情程度和预后评估的生物指标。

Objective：To investigate the correction of plasma D-dimer,fibrinogen levels with the traumatic degree of patients with orthopedic trauma.Methods：One hundred and eighty patients with orthopedic trauma in our hospital from January 2015 to January 2016 were selected as the observation group,and one hundred healthy people in the same period were chosen as the control group.The plasma D-dimer and fibrinogen levels from 1st to 10th day after admission were compared,and the correction of plasma D-dimer （DD）,fibrinogen （FIB） levels with the traumatic degree were analyzed.Results：The DD and FIB levels in observation group were obviously lowered,which were significantly higher than those of the control group （P〈0.05）.The DD and FIB levels in serious injury group and moderated injury group were much higher than those of the slight injury group,and those in serious injury group was the highest （P〈0.05）.And DD and FIB levels in the three groups had a remarkable decrease from 1st to 10th day （P〈0.05）.Additionally,plasma D-dimer and fibrinogen levels were significantly and positively correlated with the orthopedic traumatic degree （r=0.64,P=0.003;r=0.71,P=0.002）.Conclusion：The levels of plasma DD and FIB in patients with orthopedic trauma were markedly higher than those of the healthy people,which were significantly and positively correlated with the orthopedic traumatic degree and could be served as a biomarker on assessment of traumatic degree and prognosis.