紫草素在消化系统肿瘤中的抗癌机制研究进展

Anticancer Research Progress of Shikonin in Neoplasms of Digestive System

消化系统肿瘤是威胁我国居民生命健康的重要杀手,其发病率和死亡率均占全部肿瘤的50%左右,研发高效安全的抗肿瘤药物是治疗消化系统肿瘤的基础。植物提取物是抗肿瘤药物的重要来源,紫草素(Shikonin)是一种存在于紫草科植物根茎中的药物成分,它对消化系统肿瘤细胞具有显著的杀伤效果。本文通过检索最近10年紫草素在消化系统肿瘤中发挥抗癌作用的相关文献,对紫草素及其衍生物在消化系统肿瘤中的抗癌机制进行系统归纳整理,并分析了今后紫草素应用于临床治疗消化系统肿瘤的研究方向,为进一步探索紫草素在消化系统肿瘤中的抗癌机制研究和新药研发提供理论依据。

Neoplasms of digestive system are great killers that threaten the residents＆#39; life and health in our country,of which the morbidity and mortality account for about 50 % of all tumors.Developing effective anti-tumor drugs is the foundation of treating digestive system cancer.Plant extracts are important sources of anticancer drugs.Shikonin is a pharmaceutical component from the root of Boraginaceae Lithospermum.It has significant killing effects on the digestive system tumor cells.We searched the articles of shikonin combined with the tumors of digestive system published in recent 10 years,analyzed the anticancer mechanisms of shikonin and its derivatives in tumors of digestive system,predicted the future research of shikonin used in clinical treatment of the digestive system tumors,and provided a theoretical foundation for further exploration of shikonin in treatment with digestive system cancer and in novel drug development.