苯磺酸氨氯地平片联合马来酸依那普利片治疗老年单纯收缩期高血压疗效观察

Clinical effect observation of amlodipine besylate tablets combined with enalapril maleate tablets in elderly with systolic hypertension alone

目的观察苯磺酸氨氯地平片联合马来酸依那普利片治疗老年单纯收缩期高血压的临床疗效。方法将120例老年单纯收缩期高血压患者随机分为A、B、C 3组,每组40例,其中,A组给予苯磺酸氨氯地平片,B组给予马来酸依那普利片,C组给予苯磺酸氨氯地平片联合马来酸依那普利片,规律用药3个月,监测用药前后的收缩压(SBP)、舒张压(DBP)、尿微量白蛋白(mALB)、舒张期左心室后壁厚度(LVPWT)的水平变化。对比3组降压效果。结果 C组的血压治疗显效率及总有效率均明显高于A、B组(P<0.05)。3组患者经过治疗SBP、DBP均低于治疗前,差异均有统计学意义(P<0.05);A组治疗后SBP低于B组,差异有统计学意义(P<0.05);C组治疗后SBP、DBP均低于A、B组,差异均有统计学意义(P<0.05)。3组患者经过治疗舒张期LVPWT较治疗前均有所下降,差异均有统计学意义(P<0.05)。B组与C组治疗后mALB均下降,且2组mALB、舒张期LVPWT均较A组下降显著,差异具有统计学意义(P<0.05)。结论苯磺酸氨氯地平片联合马来酸依那普利片治疗老年单纯收缩期高血压疗效优于单药治疗。

Objective To observe the clinical effect of amlodipine besylate tablets combined with enalapril maleate tablets in elderly with systolic hypertension alone.Methods 120 cases patients with elderly with systolic hypertension alone were randomly divided into A group,B group and C group,each of 40 cases.Group A was given amlodipine besylate,group B was given enalapril maleate tablets,group C was given amlodipine besylate combined with enalapril maleate tablets,.Regular medication 3 months,monitor and compared the systolic blood pressure（SBP）,diastolic blood pressure（DBP）,urine microalbumin（mALB）,diastolic left ventricular posterior wall thickness（LVPWT） among 3 groups.Compared the antihypertensive effect of 3 groups.Results The significant efficiency and total efficiency of group C was higher than that of group A and group B（P〈0.05）.After treatment,the level of SBP、DBP of 3 groups were lower than that before treatment,the difference was statistic significantly（P〈0.05）.The level of SBP after treatment of group A was lower than that of group B,the difference was statistic significantly（P〈0.05）.The level of SBP、DBP of group C after treatment was lower than that of group A and group B,the difference was statistic significantly（P〈0.05）.After treatment,the level of diastolic LVPWT of 3 groups were lower than that before treatment,the difference was statistic significantly（P〈0.05）.After treatment,the mALB in group B and group C were lower than before treatment,and the mALB and diastolic LVPWT in these 2 groups were lower than those in the group A,the differences were statistically significant（P〈0.05）.Conclusion The clinical effect of amlodipine besylate tablets combined with enalapril maleate tablets in elderly with systolic hypertension alone is better than monotherapy.