骨疏颗粒对去势雌性大鼠骨关节炎的影响观察

Experimental Study of Effects of Gushu Granules on Osteoarthritis of Ovariectomized Osteoporotic Model Rats

观察骨疏颗粒对去势雌性大鼠骨关节炎模型的性激素、炎性因子影响,以及骨疏颗粒治疗去势后雌性大鼠骨关节炎的疗效.将60只SD大鼠随机分为4组:模型组、正常对照组、戊酸雌二醇组、骨疏颗粒组.采用卵巢摘除联合过度运动制作骨关节炎模型,观察大鼠性激素、炎性因子改变.结果表明,与模型组比较,骨疏颗粒组及雌激素组均可以改善去势雌性大鼠性激素、炎性因子水平(P<0.01或P<0.05),二者之间无显著差异(P>0.05).骨疏颗粒能治疗和延缓去势雌性大鼠骨关节炎病变,与戊酸雌二醇无显著性差异.

Objective To investigate the effect of Gushu granules on osteoarthritis ovariectomized osteoporotic model rats. In order to provide experimental basis for clinical application of Gushu granules and further study. 60 SD rats were randomly divided into 4 groups i. e. model group, normal control group, estrogen group and group of Gushu granules. The osteoporosis model was induced by ovariectomy and overexercise, the change of sex hormone and inflammatory factor in rads were observed after the rats were treated with Gushu granules and estradiol valerate. The experimental results show Gushu granules and estradiol valerate could in- crease the level of sex hormone and reduce inflammatory factor of osteoarthritis model rats（P〈0.01 or P〈 0.05）. Significant difference is compared with model group （P〈0.05）. There is no significant difference between the two（P〈0.05）. It is concluded that the Gushu granules could treatment and delay osteoarthritis. There is no significant difference with estradiol valerate.