来曲唑与黄体酮联合使用治疗多囊卵巢综合征不孕的临床疗效及对患者机体卵巢功能的影响

The clinical efficacy of letrozole combined with progesterone in the treatment of patients with polycystic ovary syndrome infertility and its effect on ovarian function

目的探究在多囊卵巢综合征不孕治疗的过程中,使用来曲唑与黄体酮联合治疗的效果和对患者卵巢功能的影响。方法选择80例多囊卵巢综合征不孕患者,随机分为对照组和观察组,各40例。对照组患者采用来曲唑治疗,研究组患者使用来曲唑、黄体酮联合治疗,观察两组患者的效果。结果观察组患者的妊娠率为50.0%(20/40),对照组患者的妊娠率为27.5%(11/40),同时在无差异的基础上分组治疗后观察组患者卵巢功能改善较对照组明显,差异有统计学意义(P<0.05)。结论来曲唑与黄体酮联合使用能够提高临床疗效,同时改善患者卵巢功能,因此值得临床借鉴。

Objective To explore the clinical efficacy of letrozole combined with progesterone in the treatment of patients with polycystic ovary syndrome infertility and its effect on ovarian function. Methods The 80 infertile women with polycystic ovary syndrome were randomly divided into control group and observation group, with 40 cases in each group. Patients in the control group were treated with letrozole, and the patients in the study group were treated with letrozole and progesterone. The effect of two groups of patients were observed and compared. Results The pregnancy rate of the observation group was 50.0% （20/40）, and the pregnancy rate of the control group was 27.5% （11/40）. The improvement of ovarian function in the observation group was sig- nificantly higher than that in the control group （P〈0.05）. Conclusion Letrozole combined with progesterone can improve clinical efficacy and improve the ovarian function of patients, so it is worthy of clinical reference.