不同剂量阿托伐他汀治疗冠心病慢性心力衰竭的疗效

Efficacy of different doses of atorvastatin in the treatment of coronary heart disease with chronic heart failure

目的探讨不同剂量阿托伐他汀治疗冠心病慢性心力衰竭的临床疗效。方法选取2014年1月-2015年12月我院收治的88例冠心病慢性心力衰竭患者,按照随机数字表法分为对照组与观察组,每组各44例。两组患者均采用常规药物治疗,对照组在常规治疗基础上加用20 mg阿托伐他汀,观察组患者在常规治疗基础上加用40 mg阿托伐他汀。观察并对比两组患者的临床疗效。结果观察组患者的左室射血分数较对照组明显提高,左室收缩末期内径以及左室舒张末期内径优于对照组,且6 min步行距离明显长于对照组,差异均有统计学意义(P<0.05)。结论采用不同剂量的阿托伐他汀治疗冠心病慢性心力衰竭疗效显著,且双倍剂量的效果更加明显,值得临床广泛推广。

Objective To explore the efficacy of different doses of atorvastatin in the treatment of coronary heart disease with chronic heart failure. Methods From January 2014 to December 2015, 88 coronary heart disease patients with chronic heart failure were enrolled in the study and randomly divided into two groups： the observation group and the control group, 44 cases in each group. The patients in the both groups accepted con- ventional drug treatment. Meanwhile, the patients in the control group accepted 20 mg atorvastatin on the basis of conventional treatment, and those in the observation group accepted 40 mg atorvastatin on the basis of con- ventional treatment. The clinical efficacy of the two groups were observed. Results Compared with the control group, the left ventricular ejection fraction of the observation group was higher, and left ventricular end systolic diameter and left ventricular end-diastolic diameter were better, and the extension of 6 min walking distance was more apparent, all with significant differences （P〈0.05）. Conclusion Different doses of atorvastatin in the treatment of coronary heart disease with chronic heart failure achieve obvious curative effect, and the effect of a double dose is more apparent and is worthy of clinical application.