487例HIV感染者所患皮肤疾病与免疫缺陷的关系

The relationship between skin diseases and immunodeficiency in 487 patients with HIV infection

目的探讨487例人类免疫缺陷病毒(human immunodeficiency virus,HIV)感染者所患皮肤疾病与免疫缺陷的关系。方法回顾性分析我院2011年1月-2015年12月间收治的487例HIV感染者的临床资料,并对患者皮肤疾病的发生与免疫缺陷之间的关系进行分析。结果与较高的CD4计数(CD4>450 cells/μL)有关的包括日光角化、基底细胞癌、原位鳞癌、痤疮、黑素细胞瘤以及脂溢性角化,与CD4计数(350 cells/μL>CD4>450 cells/μL)有关的包括干燥症、瘙痒症、病毒疣、湿疹、侵袭性鳞状细胞癌、脂溢性皮炎、浅部真菌感染、肛周癌前病变,与CD4计数(250 cells/μL>CD4>350 cells/μL)有关的包括带状疱疹、药疹、单纯疱疹、细菌性毛囊炎、结节性痒疹,与CD4计数(CD4<250 cells/μL)有关的包括嗜酸性毛囊炎、传染性软疣。结论 487例HIV感染者罹患皮肤疾病与免疫缺陷密切相关。

Objective To investigate the relationship between skin diseases and immunodeficiency in 487 patients with human immunodeficiency virus （HIV） infection. Methods The clinical data of 487 patients with HIV infection in our hospital from January 2011 to December 2015 were retrospectively analyzed. The relationship between the incidence of skin diseases and immunodeficiency were explored. Results Higher CD4 count （CD4〉450 cells/μL） was associated with solar keratosis, basal cell carcinoma, squamous cell carcinoma, acne, melanoma and seborrheic keratosis; and the CD4 count （350 cells/μL〉CD4〉450 cells/μL） was associated with xerostomia, pruritus, eczema, viral warts, invasive squamous cell carcinoma, seborrheic dermatitis, superficial fungal infections and perianal precancerous lesions; and CD4 count （250 cells/μL〉CD4〉350 cells/μL） was associated with herpes zoster, drug rash, herpes simplex, bacterial folliculitis, prurigo nodularis; and CD4 count （CD4〈250 cells/μL） was related with eosinophilic folliculitis and molluscum contagiosum. Conclusion Skin dis- eases are closely associated with immunodeficiency in 487 patients with HIV infection.