米非司酮治疗功能失调性子宫出血的临床疗效及安全性分析

Analysis of Clinical Efficacy and Safety of Mifepristone in the Treatment of Dysfunctional Uterine Bleeding

目的:研究讨论围绝经期功能失调性子宫出血(以下简称围绝经期功血)在米非司酮的治疗下所取得的临床效果。方法:将124例围绝经期功血的病患随机划分为对照组和观察组,每组62人。对照组采用炔诺酮进行治疗,观察组采用米非司酮进行治疗,两组疗程都为6个月。在治疗前后会定时对病患的5项血清内分泌水平进行检测,并将治疗前后病患的子宫内膜厚度相互比较。结果:炔诺酮组治疗的有效率明显低于米非司酮组治疗的有效率(P<0.05);经过治疗后的实验组促黄体生成素(LH)与促卵泡生成素(FSH)水平和治疗前的水平相比并没与明显差异(P>0.05),然而雌二醇(E2)与血清孕酮(P)水平与治疗前相比下降明显(P<0.05),同时与治疗前相比泌乳素(PRL)的水平也有一定程度下降;子宫内膜增生经米非司酮治疗以后效果明显(P<0.01)。不良反应中,两组没有明显差异(P>0.05)。结论:米非司酮能够作为安全有效的一种治疗围绝经期功血优先选择的药物,其具有较高的临床使用意义。

Objective：To study and discuss the clinical effect of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding （hereinafter referred to as the perimenopausal dysfunctional uterine bleeding）.Methods：124 cases of perimenopausal dysfunctional uterine bleeding patients were randomly divided into control group and observation group,with each group of 62 people.The control group was treated with mifepristone,the observation group was treated with mifepristone,who were treated for 6 months.The 5 items of serum endocrine level were detected before and after treatment, and the endometrial thickness of patients before and after treatment were compared with each other.Results：The effective rate of norethindrone group was significantly lower than that of mifepristone group （P〈0.05）.There was no significant difference between the levels of luteinizing hormone （LH） and follicle-stimulating hormone （FSH） and the level before treatment （P〉0.05）.However,the levels of estradiol （E2） and serum progesterone （P） decreased signifi-cantly compared with those before treatment （P〈0.05）,the levels of PRL decreased to some extent compared with those before treatment,and the effect of mifepristone in the treatment of hyperplasia endometrii was significant （P〈0.01）.There was no significant difference between the two groups in the adverse reactions （P〉0.05）.Conclusion： Mifepristone can be used as a safe and effective medicine for the treatment of perimenopausal dysfunction,which has a high clinical significance.