胃癌组织中p53、Ki67表达与患者生存质量及预后的关系

The relationship between the expression levels of p53 and Ki67 in gastric cancer tissues and the quality of life and clinical prognosis of patients with gastric cancer

目的探讨胃癌组织中p53、Ki67表达与胃癌患者生存质量及预后的关系。方法回顾性分析本院2009年5月至2012年5月收治的行胃癌切除术的1135例患者的临床资料,其中1035例患者完成随访,收集患者胃癌组织中p53、Ki67的表达情况,记录患者转移、复发及死亡情况,所有患者均采用SF-36简明健康状况调查量表(MOS 36-item short form health survey,SF-36)进行生存质量评分,分析胃癌组织中p53、Ki67表达与患者生存质量及预后的关系。结果 1035例患者中,p53阳性407例、阴性628例;Ki67阳性306例、阴性729例。p53阳性患者的总体健康、生理功能、活力、情感职能、精神健康、社会功能评分均明显低于p53阴性患者(P<0.05),Ki67阳性患者的总体健康、生理功能、活力、情感职能、精神健康、社会功能评分均明显低于Ki67阴性患者(P<0.05)。Logistic分析结果提示,p53阳性(P=0.03)、Ki67阳性(P=0.02)、TNM分期(P=0.02)是胃癌患者预后不良的独立危险因素。结论胃癌组织中p53、Ki67表达与患者生存质量及预后密切相关。

Objective To investigate the relationship between the expression levels of p53 and Ki67 in gastric cancer tissues and the quality of life and clinical prognosis of patients with gastric cancer. Method The clinical data of 1135 patients with gastric cancer in our hospital from May 2009 to May 2012 were retrospectively analyzed, 1035 patients completed follow-up, collected the expression of Ki67 and p53 in patients with gastric cancer, recorded of patients with metastasis, recurrence or death, all patients were assessed with MOS 36-item short form health survey （SF-36） to explore the relationship between the expression levels of p53 and Ki67 in gastric cancer tissues and the quality of life and clinical prognosis. Result In 1035 patients, 407 patients with p53 positive, 628 patients with p53 negative; 306 patients with Ki67 positive, 729 patients with Ki67 negative. The general health, physical function, vitality, role emotional, mental health and social function scores of p53 positive patients were significantly lower than those of p53 negative patients （P 〈 0.05）. The general health, physiological function, vitality, role emotional, mental health and social function scores of Ki67 positive patients were significantly lower than those of Ki67 negative patients （P 〈0.05）. Logistic analysis showed that p53 positive （P = 0.03）, Ki67 positive （P = 0.02）, and TNM stage （P= 0.02） were the independent risk factors for poor prognosis in patients with gastric cancer. Conclusion The expression levels of p53 and Ki67 in gastric cancer are closely related to the quality of life and prognosis.