沉思在抑郁症患者负性生活事件与抑郁间的中介效应

The mediating effects of rumination on the relationship between negative life events and depressive symptoms in treatment-naive depressed patients

目的探讨沉思及其2种亚型（冥思与反思）在抑郁症患者负性生活事件与抑郁症状之间的中介作用。方法招募62例抑郁症患者，所有被试均接受流调中心用抑郁量表、沉思反应量表、生活事件量表测评。结果①抑郁症患者的抑郁症状与沉思总分、冥思及其负性生活事件呈正相关（r=0．66，P〈0.01；r=0．50，P〈0.01；r=0．51，P〈0.01）；沉思总分及其冥思得分与负性生活事件得分之间呈正相关（r=0．45，P〈0.01；r=0.47，P〈0.01）；②沉思总分在抑郁症患者负性生活事件与抑郁症状之间的中介作用显著（中介效应值=0．12，95％CI：0.04～0．23）；③沉思的2种亚型中，只有冥思在抑郁症患者负性生活事件与抑郁症状之间的中介作用显著（中介效应值=0．07，95％CI=0．02—0．15）。结论沉思及其亚型冥思在抑郁症患者负性生活事件与抑郁症状之间存在中介作用。

Objective To explore the mediating effects of rumination and its subtypes on the rela-tionship between negative life events and depressive symptoms in treatment-naive depressed patients. Methods Sixty-two treatment-naive depressed patients completed the center for epidemiologic studies depression scale（ CESD）, rumination response scale （ RRS）, and life event scale （ LES ）. Results ① The scores of CESD were positively correlated with total score of RRS, brooding score of RRS, and negative LES score （NLES） in depressed patients（ r=0.66, P〈0.01 ; r= 0.50, P〈0.01 ; r= 0.51, P〈0.01）.The total score of RRS and brooding score of RRS were positively correlated with NLES（ r= 0.45, P〈0.01 ; r= 0.47, P〈0.01 ）, ②The total score of RRS played a mediating role between NLES and CESD （indirect effect = 0.12,95% CI = 0.04 - 0.23）. ③The brooding of RRS played a mediating role between NLES and CESD （indirect effect = 0.07, 95% CI= 0.02 - 0.15）. Conclusion The RRS and the brooding of RRS exert mediation effects on the relationship between NLES and CESD in patients with depression.