针刺结合纳洛酮治疗重度急性酒精中毒40例临床观察

Clinical Observation of 40 Cases of Acupuncture Combined with Naloxone for Severe Acute Alcoholism

目的:观察针刺结合纳洛酮治疗重度急性酒精中毒临床疗效。方法:将80例重度急性酒精中毒患者随机分为2组各40例。对照组予常规基础治疗加用纳洛酮治疗;治疗组在对照组治疗方案的基础上加针刺治疗。观察2组患者格拉斯哥昏迷评分(GCS),比较2组清醒时间、清醒后主诉症状情况以及纳洛酮人均使用量。结果:治疗后,2组GCS评分分别与治疗前比较,差异均有统计学意义(P<0.01);治疗组GCS评分高于对照组,差异有统计学意义(P<0.01);治疗组清醒时间短于对照组,差异有统计学意义(P<0.01);2组患者清醒后,对照组主诉症状较治疗组多,临床不舒适率高于治疗组,差异均有统计学意义(P<0.01);治疗后,治疗组纳洛酮人均用量低于对照组,差异有统计学意义(P<0.01)。结论:针刺结合纳洛酮治疗重度急性酒精中毒疗效良好,能减少解酒药物药量的使用,较为快速醒酒,改善患者酒精中毒症状,提高患者的临床舒适度。

Objective：To observe the clinical effect of acupuncture combined with naloxone on treating severe acute alcoholism. Methods：Divided 80 cases of patients with severe acute alcoholism into two groups randomly,40 cases in each group. Both groups were treated with routine basic treatment combined with naloxone, while the treatment group was additionally treated with acupuncture. Observed Glasgow coma scale（GCS） in both groups. Compared consciousness time,self-reported symptoms after patients were conscious and the dosage of naloxone for each patient between both groups.Results：After treatment,compared GCS scores in both groups with those before treatment,the difference being significant（P〈0.01）,and GCS score in the treatment group was higher than that in the control group,the difference being significant（P〈0.01）. The consciousness time in the treatment group was shorter than that in the control group,the difference being significant（P〈0.01）. After patients became conscious,there were more self-reported symptoms in the control group,and the discomfort rate in the control group was higher than that in the treatment group,differences being significant（P〈0.01）.After treatment,the dosage of naloxone for each patient in the treatment group was lower than that in the control group,the difference being significant（P〈0.01）. Conclusion：The therapy of acupuncture combined with naloxone for severe acute alcoholism has good curative effect. It can reduce the use of antialcoholic drug, dispel the effects of alcohol quickly and improve the symptoms of alcoholism,and it is comfortable for patients clinically.