注射用炎琥宁雾化治疗支气管哮喘急性期患儿的疗效与炎性因子观察

Observe the Curative Effect and Inflammatory Factors in Children With Potassium Sodium Dehydroandroandrographolide Succinate for Injection Inhalation in the Treatment of Acute Bronchial Asthma

目的观察注射用炎琥宁雾化吸入治疗急性期支气管哮喘患儿的临床疗效以及对患儿血清炎性因子表达水平的影响。方法以本院2015年1月—2016年6月收治的64例支气管哮喘急性期患儿作为本次观察对象,将全部患儿以随机法分别划入对照组与观察组,对照组采取常规治疗,观察组在常规治疗的同时给予炎琥宁雾化吸入治疗;治疗3 d后评估临床疗效,同时检测两组患儿血清中炎性因子白介素-4(IL-4)、白介素-13(IL-13)、肿瘤坏死因子(TNF-α)水平并进行对比。结果治疗后3 d时,观察组显效率为50.00%,总有效率为90.63%;对照组显效率为28.13%,总有效率为65.63%;观察组疗效优于对照组,P<0.05;观察组TNF-α、IL-4、IL-13的表达水平均低于对照组,P<0.01。结论注射用炎琥宁雾化治疗支气管哮喘急性期患者疗效理想,能够有效降低血清炎性因子的表达水平。

Objective To observe the clinical efficacy of atomizing inhalation of Potassium Sodium Dehydroandroandrographolide Succinate for Injection in treatment of acute bronchial asthma and the effect on expression level of serum inflammatory factors. Methods 64 cases of patients with acute bronchial asthma of children in our hospital from January 2015 to June 2016 were as the observation object, all patients were randomly assigned to respectively control group and observation group, the control group received routine treatment, observation group were given conventional treatment and Yanhuning atomization inhalation treatment; clinical curative effect evaluation of treatment after 3 D at the same time in two groups were detected the serum inflammatory cytokine interleukin -4 （IL-4）, interleukin -13 （IL-13）, tumor necrosis factor （TNF-） level and compared. Results after 3 days the treatment, the observation group was 50% efficiency, the total effective rate was 90.63%; the control group was 28.13%, the total efficiency of 65.63%; observation group than the control group, P 〈 0.05; the expression level of TNF- alpha, IL-4, observation group IL-13 was lower than the control group, P〈0.01. Conclusion Potassium Sodium Dehydroandroandrographolide Succinate for injection inhalation in the treatment of acute bronchial asthma patients with ideal curative effect, can effectively reduce the expression level of serum inflammatory factors.