MDSC的免疫调节机制及其在免疫治疗中的作用

Immune Regulation Mechanism of MDSC and Its Role in Immunotherapy

肿瘤微环境由通过癌细胞和周围基质细胞之间复杂的相互作用产生的免疫抑制性网络组成。这种环境的一个关键组成部分是髓源性抑制细胞(MDSC),代表未成熟骨髓细胞的异质群体,在分化的不同阶段停滞,并响应各种肿瘤因子而扩增。此外,这些细胞获得抑制表型,表达抗炎细胞因子和活性氧和氮物质,并抑制T细胞免疫应答。MDSC在调节免疫效应细胞和恶性细胞之间的相互作用中发挥不同的作用,其数量增加与肿瘤发生进展,不良预后和免疫治疗策略有效性降低相关。了解MDSC的免疫调节功能及机制有助于探求有效的免疫治疗策略。

Tumor microenvironment is composed of immunosuppressive networks produced by complex interactions between cancer cells and surrounding stromal cells.A key component of the environment is myeloidderived suppressor cells（MDSCs）,heterogeneous populations representing immature bone marrow cells,stagnating at different stages of differentiation,and amplifying in response to various tumor factors.In addition,these cells obtained inhibition of phenotype,expressed anti-inflammatory cytokines,reactive oxygen species and nitrogen substances,and inhibited the T cell immune response.MDSC plays a different role in regulating the interaction between immune effector cells and malignant cells,and the expansion of MDSCs is associated with tumor progression, poor prognosis and reduced efficacy of immunotherapy strategies.Understanding the immune function and mechanism of MDSC can help to explore effective immunotherapy strategies.