参芪扶正注射液联合TP方案治疗卵巢癌的临床分析

Clinical analysis of Shenqi Fuzheng Injection combined with TP regimen in the treatment of ovarian cancer

目的探讨参芪扶正注射液联合TP方案治疗卵巢癌的临床效果。方法回顾性分析2013年2月~2016年1月我院收治的50例卵巢癌患者的临床资料,根据患者的临床资料分为观察组和对照组,每组25例。两组患者均接受紫杉醇+铂类(TP方案)治疗,观察组加用参芪扶正注射液治疗,250 ml参芪扶正注射液静脉滴注,1次/d,3周为1个治疗周期。比较两组患者的治疗效果,生活质量(KPS)评分和不良反应发生率。结果两组患者的总有效率和疾病控制率差异无统计学意义(P>0.05)。观察组患者KPS评分改善率为96.0%,对照组为72.0%,两组差异有统计学意义(P<0.05)。观察组患者白细胞减少、脱发、骨髓抑制、呕吐恶心及胃肠道反应等反应发生率均低于对照组,差异有统计学意义(P<0.05)。结论参芪扶正注射液联合TP方案治疗卵巢癌的临床效果显著,能够提高患者的生活质量,减少化疗引起的不良反应,提高患者对药物的耐受性,对患者良好预后有积极意义,值得临床推广应用。

Objective To investigate the clinical effect of Shenqi Fuzheng Injection combined with TP regimen in the treatment of ovarian cancer.Methods From February 2013 to January 2016,clinical data of 50 patients with ovarian cancer treated in our hospital were retrospectively analyzed and patients were divided into the observation group（n=25）and the control group（n=25） according to clinical data of patients.Both groups were treated with Taxol and Platinum（TP regimen）.On the basis,the observation group was treated with Shenqi Fuzheng Injection,intravenous drip of 250 ml Shenqi Fuzheng Injection,once a time,and 3 weeks was a cycle.The efficacy of treatment,quality of life（KPS） and the incidence of adverse reactions were compared between two groups.Results There was no significant difference in the total effective rate and disease control rate between the two groups（P〉0.05）.The improvement rate of KPS score in the observation group was 96.0% while in the control group was 72.0%,and there was a statistical difference between two groups（P〈0.05）.The incidence rate of leukopenia,hair loss,bone marrow suppression,vomiting and nausea,gastrointestinal reactions and other adverse reactions in the observation group were lower than those in the control group,the differences were statistically significant（P〈0.05）.Conclusion The clinical effect of Shenqi Fuzheng Injection combined with TP regimen is significant in the treatment of ovarian cancer.It can significantly improve the quality of life of patients,reduce the adverse reactions caused by chemotherapy,and improve patients′ tolerance to drugs,which has positive effect on the prognosis of patients,it is worthy of clinical prumotion an application.