血管内皮细胞损伤和修复与2型糖尿病阿司匹林抵抗的相关性研究

Relationship between injury and repair of vascular endothelial cells and aspirin resistance in patients with type 2 diabetes mellitus

目的:研究血管内皮细胞损伤和修复与2型糖尿病阿司匹林抵抗的相关性。方法:选择2013年—2014年收治的2型糖尿病患者310例,其中符合入选标准298例。根据TEG检测结果将患者分为阿司匹林抵抗组42例和阿司匹林敏感组256例。所有患者每天口服>100 mg的阿司匹林,1周后,抽取患者静脉血,置于枸橼酸和肝素试管中。检测血小板抑制率。以患者发病时间为起点进行为期12个月的随访,检测患者外周血中的血管内皮细胞的数量。结果:患者服用阿司匹林1周后,阿司匹林敏感组和阿司匹林抵抗组循环内内皮细胞的数量为(4.2±1.6)个和(3.3±1.1)个,随访1年后分别为(5.2±1.4)个和(2.2±0.7)个,两组患者在不同时间段循环内内皮细胞数量比较,差异有统计学意义,P<0.05。结论:血管内皮细胞损伤与阿司匹林抵抗具有明显的相关性,科学有效地降低阿司匹林抵抗率能够有效降低糖尿病患者并发心脑血管血栓性疾病的发生率,减少血管内皮细胞的损伤程度。

Objective：The relationship between injury and repair of vascular endothelial cells and aspirin resistance in pa- tients with type 2 diabetes meUitus. Methods ： From 2013 to 2014,310 cases of patients with type 2 diabetes as the research object,which meet the inclusion criteria for 298 cases. According to TEG test, the patients were divided into aspirin resistance group（42 cases） and aspirin -sensitive group（256 cases）. All patients with daily oral administration of 〉 100 mg aspirin, a week after the extraction of venous blood in patients, citrate and heparin in vitro. In the detection of platelet inhibition rate. The number of vascular endothelial cells in peripheral blood of patients was detected by 12 months of follow- up. Results：The num- ber of circulating endothelial cells was （4.2 ~ 1.6） and （ 3.3 ~ 1.1 ） in the aspirin - sensitive and aspirin - resistant groups after one week of aspirin administration. After one year of follow - up （5.2 ＋ 1. g vs 2.2 ＋ 0.7 ）, two groups of patients on the number of bad in endothelial cells have significant difference in different time periods （ P 〈 0.05 ）. Conclusion： Vascular endo- thelial cell injury and aspirin resistance has obvious relevance, scientific and effective to reduce the prevalence of aspirin resist- ance can effectively reduce cardiovascular thrombotic diseases in patients with diabetes incidence, reduce the degree of injury of vascular endothelial cells.