儿童再发性腹痛与食物不耐受及食物过敏的相关性研究

Relationship between recurrent abdominal and pain food intolerance,food allergy in children

目的探讨食物不耐受(FI)及食物过敏(FA)与再发性腹痛(RAP)的相关性。方法选择55例RAP患儿为观察组及50例体检健康儿童为对照组。实验室检测血清特异性IgG、IgE,观察患儿白细胞计数、嗜酸性粒细胞计数及C-反应蛋白;比较2组儿童FI及FA分布情况,分析FI与RAP的相关性。结果 2组排在前3位的不耐受食物依次为牛奶(67.27%vs18.00%)、鸡蛋(50.91%vs 16.00%)和鳕鱼(41.82%vs 10.00%),观察组患儿不耐受比例显著高于对照组儿童(χ~2=25.830,P=0.000;χ~2=14.166,P=0.000;χ~2=13.559,P=0.000)。观察组患儿对玉米、螃蟹、蘑菇、虾及大豆等五种食物的不耐受比例显著高于对照组儿童(P<0.05)。2组儿童过敏食物比例比较无显著差异(P>0.05)。与RAP患儿FI相关因素有白细胞、嗜酸性粒细胞及C-反应蛋白增多(P<0.05)。结论 FI可能是导致RAP发生的重要原因之一,与RAP患儿FI相关因素有白细胞、嗜酸性粒细胞及C-反应蛋白增多。

Objective To investigate the （RAP） and food intolerance （FI）, food allergy （FA） correlation between recurrent abdominal pain in children. Methods A total of 55 children with RAP were selected as observation group and 50 healthy children were selected as control group. The levels of serum specific gastrointestinal hormone including IgG and IgE were detected. The level of white blood cell count, eosinophil count and C-reactive protein were observed. The distribution of FI and FA were compared between the two groups, and the correlation between FI and RAP was ana- lyzed. Results In the two groups, the top three intolerance foods were milk （67.27% vs 18% ）, egg （50.91% vs 16% ） and cod （41.82% vs 10% ）. The rate of intolerance in the observation group was significantly higher than that of the control group respectively （ x2 = 25. 830, P = 0.000 ; X2 = 14. 166, P =0. 000; x2 = 13. 559, P =0. 000）. The rates of intolerance of corn, crab, mush- room, shrimp and soy in the observation group were significantly higher than those of the control group respectively （P 〈 0.05 ）. There was no significant difference in the rate of allergic food between the two groups （P 〉 0.05 ）. The related factors of FI in children with RAP were the increase of white blood cells, eosinophils and C-reactive protein （ P 〈 0.05 ）. Conclusion FI may be an important cause of the occurrence of RAP. The related factors of FI in children with RAP are the increase of white blood cells, eosinophils and C-reactive protein.