新生儿黄疸患儿血清非结合胆红素及白蛋白检测的应用价值分析

Application value of serum unconjugated bilirubin and albumin detections in children with neonatal jaundice

目的观察和分析新生儿黄疸患儿血清非结合胆红素(UCB)及白蛋白(ALB)检测的应用价值。方法选取285例新生儿黄疸患儿作为研究对象,对其血清UCB、总胆红素(TBIL)、ALB及β_2微球蛋白(β_2-MG)水平进行检测和比较。结果重度黄疸的新生儿血清UCB、TBIL、UCB/ALB、β_2-MG水平均显著高于中度黄疸患儿(P<0.05)。有核黄疸的新生儿血清UCB、TBIL、UCB/ALB、β_2-MG水平均显著高于无核黄疸患儿(P<0.05)。感染性黄疸患儿的血清UCB、TBIL、UCB/ALB、β_2-MG水平显著高于其他3种病因类型(P<0.05)。结论新生儿黄疸患儿的血清UCB及UCB/ALB水平与其病情严重程度和病因类型具有一定的相关性。

Objective To observe and analyze the application value of serum unconjugated bilirubin （UCB） and albumin （ALB） detections in children with neonatal jaundice. Methods A to- tal of 285 children with neonatal jaundice were selected. The serum UCB, total bilirubin （TBIL）, ALB and BE microglobulin （β2-MG） levels of the children were detected and compared. Results The serum UCB, TBIL, UCB/ALB, β2-MG levels in children with severe jaundice were significantly higher than those with moderate jaundice （P 〈 0.05 ）. The serum UCB, TBIL, UCB/ALB, β2-MG levels in children with nuclear jaundice were significantly higher than those without nuclear jaundice （P 〈 0.05 ）. The serum UCB, TBIL, UCB/ALB, β2-MG levels in children with infectious jaundice were significantly higher than those with other three etiological types （P 〈 0.05 ）. Conclusion The serum UCB and UCB/ALB levels in the children with neonatal jaundice are correlated with the severi- ty of the disease and the etiological type.