摘要
探讨了廉价易得、环境友好的N-((吡咯-2-)甲基)-3-羟基萘-2-甲酰胺催化的吲哚与硝基烯烃不对称Friedel-Crafts烷基化反应。研究表明,在35℃条件下,CH_2Cl_2为溶剂、催化剂用量为10 mmol%、反应11 h,吲哚及1-位或2-位被取代的吲哚与硝基烯烃能有效地进行Friedel-Crafts烷基化反应,可获得较好的产率。该反应具有催化剂经济易得且用量少、反应条件温和、环境友好、操作简单等优点。
An inexpensive and enironmentally friendly 3-hydroxy-N-（（ pyrrolidin-2-ly） methy） naphthalene-2-carboxamide asymmetric Friedel-Crafts alkylation of indole with β-nitrostyrenes including free-NH indoles and N or C2-substituted indoles has been developed. The reaction was 11 hours efficiently performed in the presence of（ 10 mmol%） at 35 ℃ in CH2Cl2,obtained in excellent yield. The procedure was characterized by lower amount of inexpensive catalyst,mild reaction condition,envronmentally benign and similicity.
出处
《化学试剂》
北大核心
2017年第5期460-466,共7页
Chemical Reagents
基金
国家自然科学基金资助项目(21362006)
