神经营养因子促进角膜上皮损伤修复的研究进展

Recent advances in neurotrophic factors promoting corneal epithelial wound healing

神经营养因子是一类由神经所支配的组织和星形胶质细胞产生的且为神经元生长与存活所必需的蛋白质分子,可支持神经元生长、发育和功能完整性,在神经系统的发育和生理功能维持中起着重要作用。神经营养因子除了对其所支配的组织发挥调节和功能性作用外,对其生理、生长及代谢也起着重要的神经营养性作用。角膜是人体神经纤维分布最密集的组织,丰富的神经增强了角膜的感觉功能,同时通过分泌多种营养和调节因子维持角膜的正常生理功能和损伤后的再生。近年来,关于神经营养因子促进角膜上皮愈合的研究取得了很大的进展。本文对近年来不同神经营养因子促进角膜上皮损伤后修复研究进展进行综述。

Neurotrophic factors are a species of protein molecules, which produced by tissue supplied by nerve and astrocytes and necessary for neuronal growth and survival. Neurotrophic factors play an important role in the development and physiological function of the nervous system. It can promote neurons growth and development, and keep neurons functional integrity. Except for the regulation and functionality action on the innervated tissue, neurotrophic factors play an important neurotrophic role for the tissue physiology, growth and metabolism. The cornea is the highest density of nerve fibers. Abundant nerve fibers enhance the sensory function. In addition, the nerve fibers can also secrete various nutrition and regulatory factors to keep the physi- ological function and regeneration. In recent years, the research of neurotrophic fac- tors on promoting corneal epithelial wound healing has made great progress. This arti- cle reviews the recent advances in different neurotrophic factors promoting the repair of corneal epithelial injury.