宣肺止嗽合剂辅助治疗咳嗽变异性哮喘的风邪犯肺证患者

Supplementary effects of Xuanfei Zhisou Mixture on cough variant asthma in patients with syndrome of wind pathogen invading lung

目的观察宣肺止嗽合剂(荆芥、前胡、桔梗等)辅助治疗咳嗽变异性哮喘风邪犯肺证患者的疗效。方法使用Stata 12.0软件将采用布地奈德福莫特罗粉吸入剂48例患者随机均分为治疗组和对照组,治疗组患者加服宣肺止嗽合剂。比较2组患者的咳嗽症状积分、咳嗽视觉模拟评分、生活质量、血嗜酸性粒细胞计数及不良反应。结果治疗组在咳嗽症状积分、咳嗽视觉模拟评分、生活质量方面要优于对照组,2组差异有统计学意义。2组血嗜酸性粒细胞计数差异无统计学意义。在治疗过程中,治疗组1例患者出现声嘶、口咽部真菌感染;对照组有1例患者出现心悸、震颤。结论宣肺止嗽合剂结合布地奈德福莫特罗粉吸入剂治疗咳嗽变异性哮喘风邪犯肺证时疗效良好。

AIM To observe the supplementary effects of Xuanfei Zhisou Mixture （Schizonepetae Herba, Peucedani Radix, Platycodi Radix, etc. ） on cough variant asthma in patients with syndrome of wind pathogen invading lung. METHODS Forty-eight patients, receiving budesonide/formoterol turbuhaler, were randomly and equally divided into trial group and control group using Stata 12.0 software. The patients in the trial group took Xu- anfei Zhisou Mixture additionally. Cough symptom score, cough visual analogue scale, quality of life, blood eosino- phil count and adverse reaction in two groups were compared. RESULTS Compared with the control group, the trial group provided more benefits in terms of cough symptom score, cough visual analogue scale and quality of life with statistical differences. There was no statistical difference in blood eosinophil count between the two groups. Adverse reactions such as hoarseness and oropharyngeal fungal infection in the trial group, and palpitation and tremor in the control group occurred in one patient in the process of the treatment, respectively. CONCLUSION Xuanfei Zhisou Mixture combined with budesonide/formoterol turbuhaler is an effective treatment method for cough variant asthma with syndrome of wind pathogen invading lung.