皮肌炎用药规律文献研究

Literature Study on Medication Rule of Dermatomyositis

目的总结中医治疗皮肌炎的处方用药规律。方法收集中国期刊全文数据库(CNKI)中1986年1月至2016年12月治疗皮肌炎的中医临床文献并建立数据库,使用Excel 2010、Access 2010软件分析数据,依托皮肌炎辨证分型分析其临床处方用药规律。结果筛选治疗皮肌炎方剂72首,药物243种,所有药物共出现3886次,分析得到治疗皮肌炎的常用药物、用药模式、用药规则、药物关联的网络化展示。黄芪、茯苓、生地黄、丹参、白术是依次排在前五位的治疗皮肌炎中药,白术、黄芪、茯苓、柴胡、甘草是依次排在前五位的治疗脾气虚证的中药。结论脾气虚证为皮肌炎的主要证型,贯穿皮肌炎发病始终,治疗多用补益脾气药物,兼以清热、活血化瘀药物。

Objective To Summarize the rule of Chinese medicine prescription in treating dermatomyositis.Methods Collected the Chinese medicine literature on dermatomyositis treatment from CNKI from January 1986 to December 2016,setting up a database. Used Excel 2010 and Access 2010 to analyze the statistics in the database.Based on the syndrome differentiation types,explores the medication rule including frequency of Chinese herbs and herb pairs used in dermatomyositis treatment. Results Totally 72 prescriptions and 243 herbs were included.According to the prescription and herbs used in ten syndrome types of five Zang-organs,the using frequency of all herbs is 3886 times. Then,the researchers formed the network demonstration of the commonly used drugs,medication pattern,medication rule and the herbal association for the treatment of dermatomyositis. The most commonly used five herbs in treating dermatomyositis are Huangqi [Astragalus mongholicus ],Fuling [Poria cocos ],Sheng Dihuang[Radix rehmanniae],Danshen [Salvia miltiorrhiza],and Baizhu [Rhizoma Atractylodis]. The top five herbs in treating spleen deficiency syndrome are Baizhu,Huangqi,Fuling,Chaihu [Radix bupleuri],and Danggui [Angelica sinensis]. Conclusion Spleen deficiency syndrome is the main type of dermatomyositis that is often dominant through the whole process of the treatment; Prescriptions functioning spleen-qi tonification were frequently used in combination with those for clearing heat,activating blood circulation and removing stasis.