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艾司西酞普兰治疗Ⅱ型双相情感障碍对抑郁及躁狂症状的影响 被引量:3

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摘要 目的分析艾司西酞普兰在Ⅱ型双相情感障碍治疗中的临床效果。方法随机选取锦州康宁医院2013-02—2016-02诊断为Ⅱ型双相情感障碍的患者50例,将患者随机分成两组,对照组患者实施常规阿米替林药物治疗,观察组患者采用艾司西酞普兰进行治疗,对比观察两组患者临床疗效及抑郁(HAMD评分)、躁狂(BR MS评分)状态的改善情况。结果两组患者治疗前,HAMD评分、BPMS评分比较,差异均无统计学意义(P>0.05)。经过2、4、6周治疗后,两组患者HAMD评分、BPMS评分均显著降低,且随治疗时间增加呈递减趋势,与之前比较,差异具有统计学意义(P<0.05);且各时间点观察组患者两项评分均显著低于对照组,差异具有统计学意义(P<0.05)。观察组不良反应发生率为8.0%,对照组不良反应法生率为32.0%,两组比较,差异具有统计学意义(χ2=16.584,P<0.01)。结论艾司西酞普兰治疗Ⅱ型双向情感障碍既可以改善患者抑郁水平又可以改善患者躁狂水平,疗效显著,不良反应低,效果好于阿米替林。 Objective To analyze the clinical effects of Escitalopram in the treatment of type II bipolar affective disorder.Methods 50 sufferers diagnosed with type II bipolar affective disorder at Jinzhou Kangning Hospital from February 2013 to February 2016 were selected and randomly divided into two groups.The control group were given conventional medication of Amitriptyline,while the observation group were given Escitalopram.The clinical effects and the improvement status of HAMD scores and BRMS scores were observed and compared between the two groups. Results Before treatment, HAMD scores and BPMS scores between the two groups showed no difference of statistical significance(P〉0.05).After 2,4 and 6 weeks of treatment,HAMD scores and BPMS scores in the two groups clearly decreased, taking the trend of progressive decrease with the increase of treatment period, with differ- ences of statistical significance(P〈0.05).HAMD scores and BPMS scores at each time point in the observation group were remarkably lower than the control group, with differences of statistical significance(P〈0.05).The adverse reac- tion rate in the observation group was 8.0%, while it was 32.0% in the control group.Comparison between the two groups showed differences of statistical significance (χ 2 = 16.584, P 〈 0.01). Conclusion Escitalopram in the treat- ment of type Ⅱ bipolar affective disorder can improve both the depression level and the mania level of the sufferers, with remarkable effects and low adverse reaction, which is superior to Amitriptyline.
作者 黄海涛
出处 《中国疗养医学》 2017年第5期527-529,共3页 Chinese Journal of Convalescent Medicine
关键词 艾司西酞普兰 双相情感障碍 抑郁 躁狂 不良反应 Escitalopram Bipolar affective disorder Depression Mania Adverse reaction
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