NF-κB通路在HIV/AIDS中的机制及中医证候中的应用

Mechanism of NF-κB Pathways in HIV/AIDS and Application in TCM Syndromes

NF-κB涉及调控细胞凋亡、增殖和炎症反应等多种重要生物学功能,近年来成为疾病免疫损伤机制的研究热点。HIV-1的不同组分对NF-κB通路都有不同程度的影响,HIV能通过TLRS介导NF-κB通路激活,影响HIV/AIDS患者体内免疫细胞凋亡和炎症反应,以及病毒复制,对HIV/AIDS发展进程和免疫损伤起着关键作用。HIV/AIDS中医证候转录组学研究,发现在不同中医证候NF-κB通路的基因表达不同,可能与HIV/AIDS不同证候的临床症状群和免疫损伤机制相关。研究NF-κB通路基因在HIV/AIDS不同中医证候的表达情况,有助于应用中医药治疗HIV/AIDS患者,提高免疫力,重建免疫平衡,为HIV/AIDS的基因精准化靶向治疗,提供了新的方向。

NF - Kappa B involves in many important biological functions, such as regulation of cell apoptosis, prolif- eration and inflammation. The research of immune mechanisms in disease become a hot spot in recent years. Different components of HIV - 1 have different effects to NF - Kappa B pathways in HIV/AIDS and NF - Kappa B pathway can be activated by TLRS mediate to influence apoptosis of immune cell, inflammatory responses and virus replication. It plays a key role in the development process of immune injury in HIV/AIDS patients. HIV/AIDS transcriptome studies TCM syn- dromes and it has found the gene expression of NF - KB pathway differences in different TCM syndromes, It may relate the clinical symptoms and immune injury of different TCM syndromes with HIV/AIDS. It can help to use Chinese medi- cine to treat HIV/AIDS patients, and improve immunity, rebuild the immune balance by research the gene expression of NF - KB pathway in different TCM syndromes with HIV/AIDS. It also can help to provide new directions for precision - targeted gene therapy to HIV/AIDS.