复方皂矾丸联合重组人粒细胞刺激因子注射液对白血病化疗后白细胞减少患者血清IL-6、IL-8及G-CSF水平影响研究

Study on Effect of Compound Zaofan Pill Combined with Recombinant Human Granulocyte Colony-Stimulating Factor Injection in Treatment of Leukemia after Chemotherapy in Serum IL-6,IL-8 and G-CSF

目的:探讨复方皂矾丸联合重组人粒细胞刺激因子注射液对白血病化疗后白细胞减少患者血清IL-6、IL-8及G-CSF水平的影响。方法:选取医院血液科诊断并治疗的白血病化疗后白细胞减少患者42例,按照随机数字表法分组,两组患者均给予常规治疗,对照组患者21例予以重组人粒细胞刺激因子注射液治疗,研究组患者21例予以复方皂凡丸联合重组人粒细胞刺激因子注射液治疗,采血测定治疗前后外周血像状况、血清IL-6、IL-8及G-CSF水平,同时对比临床疗效及不良反应状况。结果:对照组治疗有效率57.14%低于研究组治疗有效率85.71%,具有统计学意义(P<0.05);与对照组比较,研究组患者治疗后血红蛋白、白细胞及血小板水平均升高,治疗后血清IL-6、IL-8水平均降低,G-CSF水平均升高,具有统计学意义(P<0.05);对照组不良反应率为14.29%(3/21),研究组不良反应率为19.05%(4/21),两组间不良率无差异(P>0.05)。结论:复方皂凡丸联合重组人粒细胞刺激因子注射液能降低白血病化疗后白细胞降低患者血清IL-6、IL-8水平,升高G-CSF水平。

Objective：To investigate the effect of Compound Zaofan Pill combined with Recombinant Human Granulocyte Colony - stimulating Factor Injection in the treatment of leukemia after chemotherapy in serum IL - 6, IL - 8 and G - CSF. Methods ： A total of 42 cases with Leukemia after chemotherapy from blood specialty in our hospital were selected and divided into 2 groups. Two groups were treated with conventional therapy. Twenty - one cases in the control group were treated with Recombinant Human Granulocyte Colony Stimulating Factor Injection and 21 cases in the treatment group were treated with Compound Zaofan Pill on the basis of the control group. Blood status, serum IL - 6, IL - 8 and G - CSF levels, clinical efficacy and adverse reaction conditions were compared after the treatment. Results ： The effective rate in the control group （57. 14% ） was lower than thetreatment group （85.71%）, with significant difference （P 〈 0. 05 ）. And compared with the control group, hemoglobin, white blood cell and platelet levels in the treatment group were higher, the serum IL -6 and IL -8 levels were lower, and the G - CSF levels was higher, with significant differ- ence （P 〈0. 05）. The adverse reaction rate of control group was 14.29% （3/21）, the adverse reaction rate of the treat- ment group was 19.05% （4/21）, and there was no difference between the two groups （P 〉 0. 05 ）. Conclusion： Com- pound Zaofan Pill combined with Recombinant Human Granulocyte Colony - stimulating Factor Injection in the treatment of leukemia after chemotherapy can reduce the levels of IL - 6 and IL - 8 and increase the level of G - CSF.