中西医结合对先兆流产早期患者的疗效及妊娠结局的影响分析

Influence of Western and Chinese Medicine Measures on Early Threatened Abortion Patients and Pregnancy Outcome

目的:分析中西医结合对先兆流产早期患者的疗效及妊娠结局的影响。方法:112例先兆流产早期患者,按数字单盲法将患者分为对照组(56例)和观察组(56例)。对照组患者采用西药治疗的方案,患者给予20mg/d的黄体酮肌肉注射,同时加服维生素E、叶酸。观察组在对照组治疗的基础上联合口服中药进行治疗。对患者进行定期回访或定期检查,详细记录两组患者治疗前后的激素含量、治疗的有效率、患者妊娠期及分娩期的不良反应、观察新生儿的不良结局等。结果:治疗前,两组患者血清中β-HGC、E2、P的含量无明显差异,对比无统计学意义(P>0.05);患者治疗后,血清中β-HGC、E2、P的含量有明显提高,但观察组患者的变化明显优于对照组,差异有统计学意义(P<0.05)。两组患者经过治疗后,观察组的总有效率91.07%明显高于对照组的总有效率75.00%(P<0.05)。两组患者在妊娠期及分娩期的并发症主要有妊娠期糖尿病、高血压,胎膜早破,产后流血等;观察组患者的并发症发生率10.71%与对照组并发症发生率12.50%无明显差异(P>0.05)。但观察组的保胎成功率92.86%明显高于对照组的保胎成功率83.93%(P<0.05);观察组的新生儿畸形、低Apgars评分、足月低体重儿的人数与对照组无明显差异,差异具无统计学意义(P>0.05)。结论:采用中西医结合的方案治疗先兆流产早期患者,能明显改善患者的激素水平,提高患者治疗的成功率,不增加妊娠期及分娩期的不良并发症,不增加新生儿不良结局的发生,值得临床采纳推广。

Objective ： To analyze the influence of Western and Chinese medicine measures on early threatened abortion patients and pregnancy outcome. Methods： A total of 112 cases of early threatened abortion patients were selected in our hospital from June 2014 to June 2016, and according to the digital single blind method, were divided into the control group （56 cases） and the observation group （56 cases）. The control group was treated with western medicine treatment program and given 20 mg/d intramuscular injection of progesterone, and vitamin E and folic acid. The observation group was treated with Western and Chinese medicine treatment. Patients were conducted regular visits or periodic inspection, a detailed record of the hormone content. The treatment efficiency, pregnancy and childbirth and the neonatal adverse outcomes were observed. Results ： Before treatment, there was no significant difference in the two groups＇ serum β- HGC, E2 and P （P 〉 0. 05）. After treatment, the contents of serum β- HGC, E2 and P increased significantly, but the chan- ges of the observation group were significantly better than the control group＇ s （ P 〈 0. 05 ）. After treatment, the total effective rate was 91.07% of the observation group and was significantly higher than the control group＇ s 75% （P 〈0. 05）. Two groups＇ periods of pregnancy and childbirth complications included gestational diabetes, hypertension, premature rupture of membranes and postpartum bleeding. But there was no significant difference between the complication rate of the observation group（ 10.71% ） and the control group（ 12.50% ） （P 〉 0.05 ）. The success rate of the observation group was 92.86% and was significantly higher than the control group＇ s 83.93%. However, there was no significant difference in the number of neonatal malformations, low Apgars score and low birth weight infants in the observation group and the control group （P 〉 0.05 ）. Conclusion ： The combination of Chinese and western medicine can obviously improve the threatened abortion patients＇ level of hormone, improve the success rate and does not increase complications during deliv- ery or increase the occurrence of neonatal adverse outcome. It is worthy of popularizing clinical adoption.