奥曲肽联用糖皮质激素治疗甲亢突眼的疗效

Efficacy of Octreotide Combined with Glucocorticoid on Hyperthyroidism Exophthalmos

目的探讨奥曲肽联用糖皮质激素治疗甲亢突眼的疗效。方法选择我院2015年1月-2016年2月收治的60例活动期甲亢突眼患者，随机分为观察组和对照组，每组30例，观察组给予奥曲肽和甲基强的松龙，对照组给予奥曲肽。比较两组患者的临床疗效、炎症反应、免疫反应和不良反应。结果①与对照组（66．67％）比较，观察组临床有效率（93．33％）明显更高，差异有统计学意义（P〈0．05）；②与对照组比较，观察组IL-6、TNF、PAF、CD8^＋更低，CD4^＋和CD4^＋／CD8^＋更高（P〈0．05）。与治疗前相比，观察组治疗后IL-6、TNF、PAF、CD8^＋降低，CD4^＋和CD4^＋／CD8^＋升高（P〈0．05）；③两组患者治疗前和治疗后肝功能指标差异无统计学意义（P〉0．05）。结论奥曲肽联用糖皮质激素对甲亢突眼的疗效显著，安全有效。

Objective To investigate the efficacy of octreotide combined with glucocorticoids in the treatment of hyperthyroidism exophthalmos. Methods 60 cases with active hyperthyroidism exophthalmos from Jan. 2015 to Feb. 2016 were randomly divided into observation group and control group with 30 cases in each group. Patients in observation group were treated with octreotide and methylprednisolone and patients in control group were given octreotide. Clinical efficacy, inflammatory response, immune response and adverse reactions were compared between the two groups. Results ①The clinical effective rate in observation group （93.33%）was significantly higher than that in control group （ P 〈 0. 05 ） ; ②IL - 6, TNF, PAF and CD8^＋ were lower, CD4^＋ and CD4^ ＋/CD8^＋ were higher in observation group than those in control group（P 〈0.05）. IL -6,TNF,PAF and CD8^＋ decreased,CD^4＋ and CD^4＋/CD8^ ＋ increased after treatment in observation group（P 〈 0.05） ; ③There was no significant difference in liver function index between the two groups before and after treatment （P 〉 0.05 ）. Conclusion Octreotide combined with glucocorticoids are effective and safe in the treatment of hyperthyroidism exophthalmos.