重症急性胰腺炎患者血清PCT含量与靶器官损伤、炎症反应程度的相关性

Correlation of serum PCT levels with target organ damage and inflammatory reaction degree in patients with severe acute pancreatitis

目的:研究重症急性胰腺炎患者血清PCT含量与靶器官损伤、炎症反应程度的相关性。方法:选择在我院确诊为急性胰腺炎的146例患者,将轻症急性胰腺炎和重症急性胰腺炎的患者分别作为轻症组和重症组,选择同期健康体检者作为对照组。采集血清并测定PCT、肝肾功能指标、炎症反应指标的含量。结果:重症组和轻症组血清中PCT、sTREM-1、IL-1β、IL-6、IL-8、IL-18、TNF-α的含量显著均高于对照组,重症组血清中PCT、sTREM-1、IL-1β、IL-6、IL-8、IL-18、TNF-α的含量显著高于轻症组;重症组血清中ALT、AST、TBIL、BUN、Scr的含量显著高于轻症组和对照组,轻症组血清中ALT、AST、TBIL、BUN、Scr的含量与对照组比较无显著性差异;重症组中PCT高含量患者血清中ALT、AST、TBIL、BUN、Scr、sTREM-1、IL-1β、IL-6、IL-8、IL-18、TNF-α的含量显著高于PCT低含量患者。结论:重症急性胰腺炎患者血清PCT含量显著升高且对肝肾功能损伤、炎症反应程度具有评估价值。

Objective：To study the correlation of serum PCT levels with target organ damage and inflammatory reaction degree in patients with severe acute pancreatitis.Methods：A total of 146 patients who were diagnosed with acute pancreatitis in our hospital between May 2014 and September 2016 were selected,the patients with mild acute pancreatitis and severe acute pancreatitis were selected as the mild group and severe group,respectively;healthy subjects who received physical examination during the same period were selected as the control group.Serum was collected to determine the contents of PCT,liver and kidney function indexes as well as inflammatory reaction indexes.Results：Serum PCT,sTREM-1,IL-1β,IL-6,IL-8,IL-18 and TNF-αcontents of severe group and mild group were significantly higher than those of control group,and serum PCT,sTREM-1,IL-1β,IL-6,IL-8,IL-18 and TNF-αcontents of severe group were significantly higher than those of mild group;serum ALT,AST,TBIL,BUN and Scr contents of severe group were significantly higher than those of mild group and control group,and serum ALT,AST,TBIL,BUN and Scr contents of mild group were not significantly different from those of control group;serum ALT,AST,TBIL,BUN,Scr,TREM-1,IL-1β,IL-6,IL-8,IL-18 and TNF-αcontents of severe group of patients with high PCT content were significantly higher than those of patients with low PCT content.Conclusions：Serum PCT levels significantly increase in patients with severe acute pancreatitis and on liver and have evaluation value for liver and kidney function damage as well as inflammatory reaction degree.