血清Periostin、VEGF、ET-1水平检测在急性冠状动脉综合征患者病情评估的临床价值研究

Clinical value of serum periostin,VEGF and ET-1 level detection in disease condition evaluation of patients with acute coronary syndrome

目的探讨血清骨膜蛋白(Periostin)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)水平与急性冠状动脉综合征患者预后的关系。方法选取2013年12月至2015年6月在重庆煤炭职业病医院心血管科住院治疗的急性冠状动脉综合征患者140例。根据患者冠状动脉病变支数、冠状动脉狭窄程度、Periostin、VEGF、ET-1,探讨Periostin、VEGF、ET-1与急性冠状动脉综合征患者预后的关系。结果随着冠状动脉病变支数及狭窄程度的增加,Periostin、VEGF、ET-1水平不断上升。140例患者中死亡17例,Periostin(P=0.024)、VEGF(P=0.030)、ET-1(P=0.024)、原发性高血压史(P=0.030)、糖尿病病史(P=0.015)是急性冠状动脉综合征患者预后的独立危险因素。结论Periostin、VEGF、ET-1是急性冠状动脉综合征患者死亡的独立预测风险因素。

Objective To investigate the relationship between serum Periostin,VEGF and ET-1 levels with the prognosis in the patients with acute coronary syndrome（ACS）.Methods One hundred and forty cases of ACS treated in the cardiology department of the Chongqing Coal Occupational Disease Hospital from December 2013 to June 2015 were selected.The relationship between Periostin,VEGF and ET-1 with the prognosis in ACS patients was analyzed according to the coronary artery lesion vessels number,coronary artery stenosis degree,periostin,VEGF and ET-1.Results With the increase of coronary artery lesion vessels number and stenosis degree,the values of periostin,VEGF and ET-1 were constantly increased,among 140 cases,17 cases died.Periostin（P=0.024）,VEGF（P=0.030） and ET-1（P=0.024）,history of essential hypertension（P=0.030） and history of diabetes（P=0.015） were the independent risk factors of prognosis in the patients with ACS.Conclusion Periostin,VEGF and ET-1 are the factors for independently predicting the death in the patients with ACS.