肝纤维化与炎性细胞因子介导的相关信号通路的研究进展

Research Progress in the Relationship of Fibrosis and Signaling Pathways Mediated by Inflammatory Cytokines

纤维化是肝脏受到损伤后的一种自我修复反应,主要伴随着细胞外基质(ECM)的大量合成以及降解不足。肝星状细胞的激活在纤维化过程中起关键作用。肝星状细胞的激活涉及多种炎性细胞因子以及相关的信号通路,包括转化生长因子β_1、血小板衍生生长因子、核因子κB通路等。在细胞因子的作用下,这些通路被激活,以自分泌或旁分泌的方式作用于肝星状细胞。肝星状细胞激活后可分化、增殖,进而分泌大量纤维蛋白等ECM。

Hepatic fibrosis is a kind of self-healing after injury. In this period, extracelluar matrix （ECM） is massively synthesized but the degradation is blocked. The activation of hepatic stellate cells plays a key role in the progress of fibrosis. The activation of hepatic stellate cells are related to multiple inflammatory cytokines together with related signaling path- ways, including transforming growth factor β1, platelet derived growth factor, nuclear factor κB, etc. These pathways are acti- vated under the effects of cytokines and then act on the hepatic stellate cells through autocrine or paracrine. Hepatic steUate cells can differentiate,proliferate and secrete large amounts of fibrin and other ECM.