Klotho蛋白在慢性肾脏病中的作用研究进展

Research Progress of Klotho in Chronic Kidney Disease

Klotho蛋白是一种单次跨膜蛋白,在临床中发挥多种重要作用。在肾脏中,Klotho蛋白参与肾脏离子通道和转运体的调节,并参与肾脏1,25-二羟维生素D3的生成调节。Klotho蛋白也参与慢性肾脏病(CKD)的发生和发展,CKD是Klotho蛋白缺乏的持续状态。Klotho蛋白的缺乏使肾脏更易受到损伤、延缓肾脏修复并促进肾脏纤维化。除了直接作用于肾脏,Klotho蛋白缺乏还会导致并加重继发性甲状旁腺功能亢进、血管钙化及内皮功能紊乱等CKD的并发症。对CKD患者来说,虽然Klotho蛋白替代疗法的研究还处在动物实验阶段,但补充外源性Klotho蛋白或增加内源性Klotho蛋白生成可能将来是防治CKD的有效、可行的治疗措施。

Klotho is a single-pass transmembrane protein and exerts multiple functions in clinical. Klotho participates in modulation of renal ion channel and transporters and renal vitamin D3 production in kidney. Recent studies show that Klotho also participates in chronic kidney diseases （CKD） progression,and CKD is the state of Klotho deficiency. Klotho deficiency makes the kidney more susceptible to insults, delays kidney regeneration, and promotes renal fibrosis. In addition to direct effects, Klotho deficiency also triggers and aggravates complications of CKD, such as secondary hyperparathyroidism, vascu- lar calcification and endothelial dysfunction. Although studies on the effect of Klotho replacement are still in animal models stage, supplementation of exogenous Klotho or upregulation of endogenous Klotho production may be effective therapeutic strategy for preventing CKD.