脓毒血症的诊断与预后相关指标

Biomarkers for Diagnosis and Prognosis of Sepsis

对脓毒症进行早期诊断是治疗的关键,但脓毒症的临床表现无特异性,早期诊断依然困难。脓毒症相关生物标志物、器官功能衰竭指标对提高脓毒症的诊断、评估和预后均有极高的临床意义,对其变化趋势进行监测可为临床早期诊断脓毒症及评估其预后提供生物学依据。此外,一些非实验室评估指标,如体温、心率、血凝、丙酮醛等均能有助于临床诊断、预后评估和对脓毒症患者的监测,然而这些潜在指标在临床上的应用还存在很大挑战。

Early diagnosis is crucial to treat sepsis and is still difficult due to non-specific clinical manifestations in sepsis. Biomarkers related to sepsis and organ dysfunction indexes are conducive to the diagnosis, assessment and prognosis for sepsis. Dynamic monitoring bio-marker alteration can provide a basis for the early diagnosis, assessment and prognosis. Moreover, other indexes such as temperature, heart rate, coagulation and acetone aldehyde also contribute to diagnose and assess the prognosis of sepsis and monitor the sepsis patients. However, these potential indexes still face great challenges in the clinical applications.