二苯基乙二胺衍生物的手性Salan配体的合成的新方法

New Method for Synthesis and Structure Change of Chiral Salan Ligands Derived from Diphenylethylenediamine Derivatives

单边氢化手性salan配体是一类发展了很久并且具有优秀手性控制能力的配体,它的合成路线相对单一,均由二胺类化合物单边保护,氢化还原,还原胺化,脱保护的方法合成,该方法能得到较高的收率但反应路线过长,步骤复杂,造成时间和试剂的浪费。本文探讨氰基硼氢化钠作还原试剂对salan配体采用质子作为保护基团,经过对反应的酸碱处理可以得到目标产物的产率较高,路线相对较短。

Unilateral hydrogenated chiral salan ligancis are a mass ot tl^a which have excellent chiral control. Their synthetic routes are relatively single and protected by diamine compounds unilateral protection, hydrogenation reduction, reductive amination and deprotection. The method can be obtained a higher yield, but reaction process is too long and the steps are complicated, causing time and reagents to waste. The synthesis of salan ligands using protons as a protecting group was studied by using sodium cyanoborohydride as a reducing reagent, the reaction system treated by acid and alkali to get the target product yield was higher, the route was shorter.