新型两亲型聚磷腈聚合物的合成

Synthesis of Novel Amphiphilic Polyphosphazenes Copolymers

以六氯环三磷腈为原料,通过开环聚合反应制备了聚二氯磷腈,并将其作为主链,并通过简单的取代反应得到带氨基的聚磷腈主链。通过一系列有机合成反应得到含胍基的疏水侧链,亲水链则是对聚乙二醇单甲醚(mPEG2000)进行巯基化。通过巯基与双键的点击化学反应,将亲疏水链接到聚二氯磷腈主链上。最后,用三氟乙酸脱去保护基,得到两亲型聚磷腈聚合物,最终结构经核磁和GPC表征。

Polyphosphazeneasbackbone was prepared by ring open polymerization as hexachlorocyclotrlplaospnazene raw materials, the polyphospbazenes as backbone containing amino groups were obtaining by the simple substitution reaetioh. The hydrophibic chain was synthesized by a series of organic synthesis reactions. Meanwhile, the hydrophilic chain was synthesized by sulfhydrylation of hydrophilic methoxy-poly（ethyleneglycol） （mPEG 2000）. The hydrophibic and hydrophilic chains were grafted onto the polyphosphazene backbone by the thiol-ene click reactions. At last, the amphiphilic polyphosphazenes eopolymers were obtained by taking off the protect groups using TFA. The structure of the compound was confirmed by HNMR and GPC.