川山橙生物碱成分研究

Study on Alkaloids in Melodinus hemsleyanus

通过乙酸乙酯萃取,硅胶柱色谱、MPLC、HPLC、Sephadex LH-20等色谱分离手段从山橙属植物川山橙中分离鉴定生物碱化合物15个。分别鉴定为分别为Melaxilline A(1),epimeloscine(2),scandine(3),epimeloscine N_4-oxide(4),scandine N_4-oxide(5),meloscandonine(6),11-methoxytabersonine(7),kopsinine(8),venalstonine(9),kopsiloscine G(10),venalstonidine(11),vindolinine(12),condylocarpine(13),scandomelonine(14)和episcandomelonine(15)。其中生物碱1、4、5、10、13、14和15为首次从该植物中分离得到。

Fifteen indole alkaloids were isolated from the total alkaloid section in Melodinus hemsleyanus. Their structures were confirmed by spectroscopic methods and literatures. The structures were identified as melaxilline A （1） , epimeloscine （2） , scandine （ 3 ） , epimeloscine N4 - oxide （ 4 ） , scandine N4 - oxide （ 5 ） , meloscandonine （ 6 ） , 11 - methoxytabersonine （7）, kopsinine （8）, venalstonine （9）, kopsiloscine G （ 10 ）, venalstonidine （ 11 ）, vindolinine （ 12 ）, condylocarpine（13） , scandomelonine（14） and episcandomelonine （15）. Alkaloids 1, 4, 5, 10, 13, 14 and 15 were reported for the first time in this plant.