超声辅助多组分法合成2-氨基-3-氰基-4H-吡喃衍生物

Ultrasonic-assisted synthesis of 2-amino-3-cyano-4H-pyrans by multicomponent reaction

以芳香醛、丙二腈及乙酰乙酸乙酯为原料在超声条件下制备2-氨基-3-氰基-4H-吡喃衍生物。单因素法考察反应条件:催化剂、溶剂、反应时间、温度及原料摩尔比对合成的影响。结果表明,在碳酸钠(10%醛)催化,超声15 min、反应温度为45℃、原料物质的量比苯甲醛∶丙二腈∶乙酰乙酸乙酯为1.0∶1.0∶1.1的最优条件下,产率可达89.4%。产物用核磁、红外及熔点进行表征。

An ultrasound-assisted synthetic method of 2-amino-3-cyano-4H-pyrans derivatives was devel-oped using aromatic aldehydes, malononitrile and ethyl acetoacetate as raw materials. Influences of cata-lysts, solvents, temperature, ultrasonic time and the quivalency of starting materials on yields were investi-gated using single factor methods. The result showed that under the sodium carbonate （10% aldehyde） ultrasound for 15 min,reactin temperature for 45℃ , n（ benzaldehyde） ： n（ malonitrile） ：n（ ethylacetoac- etate） =1.0 ：1.0 ：1. 1 ,under the optimized conditoins,2-amino-3-cyano-4H-pyrans derivatives yielded in 89. 4%. Identity of the products were characterized by NMR,IR and m.p.