一种咪唑并吩嗪内酰胺反应型识别氰离子的荧光探针

A Novel Imidazophenazine Lactam Reaction Type Recognition Cyanide Ion Fluorescence Probe

设计合成了一种新型咪唑并吩嗪内酰胺荧光传感器分子(S1),通过核磁共振氢谱、碳谱和高分辨质谱等手段对其结构进行了表征,并测定了S1在二甲基亚砜(DMSO)溶液中的荧光光谱,其最大荧光发射波长为524 nm.S1的DMSO溶液具有亮黄色荧光.当在S1的DMSO溶液中分别加入F^-,Cl^-,Br^-,I^-,AcO^-,H_2PO_4^-,HSO_4^-,ClO_4^-和SCN^-等阴离子后,发现只有CN^-的加入使S1的荧光光谱出现明显的下降并发生红移.其溶液荧光颜色由黄色变为橘红色,说明S1对CN^-具有良好的专一选择性.抗干扰实验结果表明,这一识别过程不受其它阴离子干扰.通过计算得到,S1对CN-的荧光光谱最低检测限为9.96×10^(-7)mol/L,这一数值低于世界卫生组织所规定的饮用水中氰离子含量.机理研究表明,S1是一种反应型识别CN^-的荧光传感器.此外,将S1负载于固态硅胶之上,制备成固体CN^-识别材料,并成功用于对固体NaCN的识别和对CN^-水溶液的检测.

A novel imidazophenazine lactam fluorescence chemosensor （S1） was designed, synthesized and characterized by 1H NMR, 13C NMR and HRMS techniques. Fluorescence spectra of SI in dimethyl sulfoxide （DMSO） solution were meas- ured. Its maximum emission wavelength was 524 nm. The DMSO solution of Sl has bright yellow fluorescence. Respectively, to the S1 solution add F-, CI-, Br-, I-, AcO-, /-/2PO-, HSO4, C10- and SCN-, the fluorescent color of the solution didn＇t change. Only the CN- addition, the fluorescent color of the S1 solution changed from yellow to orange-red, indicating that Sl has good specific selectivity for CN-. The results of anti-disturbance experiment demonstrated that Sl detect CN- without interference from other anions. By calculation, the linear of the fluorescence of the sensor for CN- is 9.96 10-7. This value is lower than the World Health Organization （WHO） provisions of the cyanide content of drinking water. Mechanism studies show that Sl is a fluorescence sensor by reactive recognition CN-. In addition, the application of sensor Sl supported on solid silica gel was used as a solid material to detecting solid NaCN and CN- in pure water.