氮杂环卡宾催化的氰基甲酸乙酯与醛亚胺的Strecker反应研究

Strecker Reaction of Ethyl Cyanoformate with Aldimines Catalyzed by N-Heterocyclic Carbene

以四氢呋喃为溶剂,氮杂环卡宾为催化剂,进行了氰基甲酸乙酯和亚胺的Strecker反应研究.实验中考察了催化剂的种类、用量及溶剂对反应的影响,确定了最优反应条件.结果显示氰基甲酸乙酯与芳香亚胺、脂肪亚胺都能发生Strecker反应,最终合成了14个α-氨基腈衍生物,产物产率最高达到93%.该反应具有操作简单,条件温和,产率高及环境友好等优点.

The Strecker reaction of ethyl cyanoformate with aldimines was carried out with N-heterocyclic carbene （NHC） as the catalyst. The reaction conditions were optimized with different catalysts, catalyst loading and various solvents. 14 a-aminonitriles were synthesized via the optimal reaction conditions. It was found that both aromatic and aliphatic aldimines were suitable electrophiles and the highest yield was 93%. The reaction has the virtue of simple operation, mild reaction condi- tion, high yield and environment friendliness.