手性硫脲催化的不对称Henry反应:以2,2,2-三氟甲基苯乙酮作为底物构筑含有CF_3的手性中心

Chiral Thiourea Catalyzed Asymmetric Henry Reaction: Construction of Stereogenic Center Bearing a CF_3 Group from 2,2,2-Trifluoroacetophenone Substrates

以2,2,2-三氟甲基苯乙酮作为三氟甲基合成砌块,探索了其在简单易得手性硫脲催化下的不对称Henry反应.该反应在奎宁衍生的双官能团手性硫脲的催化作用下,以较高的产率和良好的对映选择性得到了具有三氟甲基取代的手性中心的产物.

An asymmetric Henry reaction with 2,2,2-trifluoroacetophenone as trifluoromethyl building block was described. This reaction was catalyzed by bifimctional thiourea derived from quinine to give the product bearing a CF3 stereogenic center in good yield with good enantioselectivity.