自噬在心血管疾病中作用的研究进展

Roles of autophagy in cardiovascular diseases：research progression

我国心血管疾病发病率和病死率高，严重威胁人们的健康和生存质量。自噬参与多种心血管疾病的发生，影响心脏功能的维持和疾病的预后，可能成为心血管疾病新的治疗靶点。现对自噬在冠心病、心肌肥厚、心力衰竭和心律失常等多种心脏疾病中作用的研究进展进行归纳总结。

The morbidity and mortality of cardiovascular diseases（CVD）are still high in our country, they severely threaten peoples health and quality of life. A dysregulated or reduced autophagy is associated with ischemic heart disease,cardiac hypertrophy,heart failure and arrhythmia. Autophagy is a key regulator in CVD development, and is essential for maintenance of heart function and improvement of prognosis. Thus, modulating autophagy represents an attractive future therapeutic target for treating cardiovascular disease. This article reviewed the research progression about effects of autophagy on ischemic heart disease,cardiac hypertrophy,heart failure and arrhythmia.