不完全川崎病患儿中脑纳利肽(BNP)的变化及临床意义

Changes of Brain Natriuretic Peptide of Children with Incomplete Kawasaki Disease and Clinical Significance

目的探讨对不完全川崎病患儿进行血浆NT-proBNP水平检测的方法及血浆NT-proBNP水平变化临床意义。方法随机选择2014年3月—2016年3月期间在该院接受治疗的不完全川崎病(IKD)患儿共35例作为研究对象,将其作为观察组,治疗后进入疾病恢复期患儿31例,同时选择同时期住院治疗的40例呼吸道感染患儿作为对照组研究对象。对两组患儿的外周血白细胞计数、C-反应蛋白、血浆NT-proBNP水平进行测定比较。结果观察组患儿外周血白细胞计数(18.25±5.42)×109/L、C-反应蛋白(80.53±41.86)mg/L和血浆NT-proBNP水平(1 370±152.00)ng/L均显著高于对照组(9.40±4.15)×109/L、(13.53±6.03)mg/L和(413±115.00)ng/L,数据比较差异有统计学意义(P<0.05);观察组患儿经过2周后31例患儿进入疾病恢复期,其中恢复期患儿外周血白细胞计数(17.53±6.25)×109/L、C-反应蛋白(70.52±35.63)mg/L和血浆NT-proBNP水平(1 368±147.00)ng/L均显著低于治疗前(9.53±2.93)×109/L、(8.53±2.76)mg/L和(501±102.00)ng/L,数据比较差异有统计学意义(P<0.05)。结论与呼吸道感染患儿相比,不完全川崎病患儿的外周血白细胞计数、C-反应蛋白及血浆NT-proBNP水平均显著较高,因此早期检测血浆NT-proBNP水平值利于不完全川崎病的诊断,实现早期诊断早日治疗。

Objective To study the test method of plasma NT-proBNP level of children with incomplete kawasaki disease and clinical significance of changes of plasma NT-proBNP level. Methods 35 cases of children with incomplete kawasaki disease treated in our hospital from March 2014 to March 2016 were selected as the observation group, 31 cases of children entered into the disease recovery stage after treatment, at the same time, 40 cases of children with respiratory tract infection at the same period were selected as the control group, and the peripheral blood leucocyte count, C-reactive protein and plasma NT-proBNP level were measured and compared. Results The peripheral blood leucocyte count, C-reactive protein and plasma NT-proBNP level in the observation group were obviously higher than those in the control group, [（18.25±5.42）×10^9/L,（80.53±41.86）mg/L,（1 370±152.00）ng/L vs（9.40±4.15） ×10^9/L、（13.53±6.03）mg/L,（413±115.00）ng/L], and the differences between groups were statistically significant（P〈0.05）, after 2-week, 31 cases of children entered into the disease recovery stage, and the peripheral blood leucocyte count, C-reactive protein and plasma NT-proBNP level were obviously lower than those before treatment, [（17.53±6.25）×10^9/L,（70.52±35.63）mg/L,（1 368±147.00）ng/L vs（9.53±2.93）×10^9/L、（8.53±2.76）mg/L,（501±102.00）ng/L], and the differences between the two groups were statistically significant（P〈0.05）. Conclusion The peripheral blood leucocyte count, C-reactive protein and plasma NT-proBNP level of children with incomplete kawasaki disease were obviously higher than children with respiratory tract infection, therefore, the early test of blood plasma NT-proBNP level is conducive to the diagnosis of incomplete kawasaki disease thus realizing the early diagnosis and early treatment.