丹参多酚酸盐对不稳定型心绞痛患者的疗效及C反应蛋白的影响

Curative Effect of Salt from Salvia Miltiorrhiza for Patients with Unstable Angina Pectoris and Effect on C-reactive Protein

目的分析和评价丹参多酚酸盐对不稳定型心绞痛(UA)的疗效及C反应蛋白(CRP)的影响。方法方便选择该院在2015年7月—2016年10月间收治的95例不稳定型心绞痛患者为研究对象,分成A组和B组,分别是49例和46例。A组给予丹参多酚酸盐治疗,B组给予丹参注射液治疗。对比临床疗效和相关因子变化。结果治疗15 d后,A组的治疗总有效率为81.63%;B组为60.87%,差异有统计学意义(P<0.05)。治疗30 d后,两组的治疗总有效率均有所提升,且A组(95.92%)高于B组(80.43%),对比有差异有统计学意义(P<0.05)。治疗15 d后,A组的CRP(C反应蛋白)(23.62±7.31)ng/L低于B组的(34.25±8.91)ng/L,对比有差异有统计学意义(P<0.05)。治疗30 d后,两组的CRP均低于治疗15 d后,且A组(15.34±5.27)ng/L低于B组(24.26±7.92)ng/L,对比差异有统计学意义(P<0.05)。结论丹参多酚酸盐治疗UA可获得显著疗效,降低CRP(C反应蛋白)水平,能够抑制血栓与血管炎症形成,有效保护血管内皮功能。

Objective To analyze and evaluate the curative effect of salt from salvia miltiorrhiza for patients with unstable angina pectoris and effect on C-reactive protein. Methods Convenient selection 95 cases of patients with unstable angina pectoris admitted and treated in our hospital from July 2015 to October 2016 were selected and divided into two groups, the group A with 49 cases adopted the salt from salvia miltiorrhiza treatment, while the group B adopted the danshen injection,and the clinical curative effect and related factor change were compared. Results After 15 d treatment, the difference in the total treatment effective rate between the group A and group B was statistically significant,（81.63% vs 60.87%）,（P〈0.05）,after 1-month treatment, the total treatment effective rate of the two groups increased, and the effective rate in the group A was higher than that in the group B（95.92% vs 80.43%）, and the difference was statistically significant（P〈0.05）, after 15 d treatment, the CRP was lower than that in the group B[（23.62±7.31）ng/L vs（34.25±8.91）ng/L], and the difference was statistically significant（P〈0.05）, after 30 d treatment, the CRP was lower than that after 15 d treatment, and the CRP in the group A was lower than that in the group B, [（15.34±5.27）ng/L vs（24.26±7.92）ng/L], and the difference was statistically significant（P〈0.05）. Conclusion The curative effect of salt from salvia miltiorrhiza in treatment of unstable angina is obvious, which can reduce the CRP level, restraint the thrombus and vascular inflammation and effectively protect the vascular endothelial function.